Compound Detail
CHEMBL381283
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Basic Information
| ChEMBL ID | CHEMBL381283 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QXCNZYXAYYZRIY-UHFFFAOYSA-N |
5
Targets
5
Activities
2
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
362.4
MW (Da)
2.30
ALogP
7
HBA
3
HBD
113.2
PSA (Ų)
0.50
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 7.75
EC50 1 meas. best 6.12
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Platelet-derived growth factor receptor beta CHEMBL2749 | IC50 | 7.75 | 7.75 | 18.0 | 1 |
| Vascular endothelial growth factor receptor 1 CHEMBL1868 | IC50 | 7.43 | 7.43 | 37.0 | 1 |
| Vascular endothelial growth factor receptor 2 CHEMBL3337 | IC50 | 7.24 | 7.24 | 57.0 | 1 |
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 7.0 | 7.0 | 100.0 | 1 |
| HMEC CHEMBL614734 | EC50 | 6.12 | 6.12 | 768.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Platelet-derived growth factor receptor beta | IC50 | = | 18.0 | nM | 7.75 | Inhibitory activity against PDGFRbeta | 16446087 |
| Vascular endothelial growth factor receptor 1 | IC50 | = | 37.0 | nM | 7.43 | Inhibitory activity against VEGFR1 | 16446087 |
| Vascular endothelial growth factor receptor 2 | IC50 | = | 57.0 | nM | 7.24 | Inhibitory activity against VEGFR2 | 16446087 |
| Fibroblast growth factor receptor 1 | IC50 | = | 100.0 | nM | 7.0 | Inhibitory activity against FGFR1 | 16446087 |
| HMEC | EC50 | = | 768.0 | nM | 6.12 | Activity against HMVEC | 16446087 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16446087 | 10.1016/j.bmcl.2006.01.020 | Vascular endothelial growth factor receptor 1 | 1 |
| 16446087 | 10.1016/j.bmcl.2006.01.020 | Vascular endothelial growth factor receptor 2 | 1 |
| 16446087 | 10.1016/j.bmcl.2006.01.020 | Platelet-derived growth factor receptor beta | 1 |
| 16446087 | 10.1016/j.bmcl.2006.01.020 | Fibroblast growth factor receptor 1 | 1 |
| 16446087 | 10.1016/j.bmcl.2006.01.020 | HMEC | 1 |
Data from ChEMBL 36 via Core Engine