Assay Detail
Binding
CHEMBL865653
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against PDGFRbeta
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Platelet-derived growth factor receptor beta (CHEMBL2749) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Design and structure-activity relationship of heterocyclic analogs of 4-amino-3-benzimidazol-2-ylhydroquinolin-2-ones as inhibitors of receptor tyrosine kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.93 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL381283 | — | — | 1 | 7.75 |
| CHEMBL204727 | — | — | 1 | 7.60 |
| CHEMBL204427 | — | — | 1 | 7.57 |
| CHEMBL204524 | — | — | 1 | 7.52 |
| CHEMBL204426 | — | — | 1 | 7.42 |
| CHEMBL205893 | — | — | 1 | 7.37 |
| CHEMBL380702 | — | — | 1 | 7.32 |
| CHEMBL204985 | — | — | 1 | 7.31 |
| CHEMBL205405 | — | — | 1 | 7.26 |
| CHEMBL383618 | — | — | 1 | 7.24 |
| CHEMBL205108 | — | — | 1 | 7.19 |
| CHEMBL383417 | — | — | 1 | 6.99 |
| CHEMBL383299 | — | — | 1 | 6.81 |
| CHEMBL205305 | — | — | 1 | 6.49 |
| CHEMBL377345 | — | — | 1 | 6.40 |
| CHEMBL383261 | — | — | 1 | 6.24 |
| CHEMBL205406 | — | — | 1 | 6.16 |
| CHEMBL206410 | — | — | 1 | 5.80 |
| CHEMBL207061 | — | — | 1 | 5.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL381283 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL204727 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL204427 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL204524 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL204426 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL205893 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL380702 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL204985 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL205405 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL383618 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL205108 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL383417 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL383299 | — | IC50 | = | 154.0 | nM | 6.81 |
| CHEMBL205305 | — | IC50 | = | 326.0 | nM | 6.49 |
| CHEMBL377345 | — | IC50 | = | 395.0 | nM | 6.40 |
| CHEMBL383261 | — | IC50 | = | 575.0 | nM | 6.24 |
| CHEMBL205406 | — | IC50 | = | 691.0 | nM | 6.16 |
| CHEMBL206410 | — | IC50 | = | 1590.0 | nM | 5.80 |
| CHEMBL207061 | — | IC50 | = | 6530.0 | nM | 5.18 |