Assay Detail
Functional
CHEMBL865710
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activity against mu opioid receptor by stimulation of [35S]GTP-gamma-S binding in CHO-hgamma cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Cell Type | CHO-hgamma |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Identification of potent phenyl imidazoles as opioid receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 7.17 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL377069 | — | — | 1 | 8.70 |
| CHEMBL205049 | — | — | 1 | 8.05 |
| CHEMBL208454 | — | — | 1 | 7.57 |
| CHEMBL204996 | — | — | 1 | 7.00 |
| CHEMBL366311 | — | — | 1 | 6.85 |
| CHEMBL205388 | — | — | 1 | 6.81 |
| CHEMBL427214 | — | — | 1 | 6.79 |
| CHEMBL361274 | — | — | 1 | 5.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL377069 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL205049 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL208454 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL204996 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL366311 | — | EC50 | = | 142.0 | nM | 6.85 |
| CHEMBL205388 | — | EC50 | = | 155.0 | nM | 6.81 |
| CHEMBL427214 | — | EC50 | = | 161.0 | nM | 6.79 |
| CHEMBL361274 | — | EC50 | = | 2445.0 | nM | 5.61 |