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Assay Detail

CHEMBL865755

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity to Dictyostelium discoideum
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Dictyostelium discoideum
Confidence 1 — Organism
Curated By Expert

Target

Dictyostelium discoideum (CHEMBL612373)
Type ORGANISM
Organism Dictyostelium discoideum

Publication

Inhibition of Trypanosoma cruzi hexokinase by bisphosphonates.
Hudock MP, Sanz-Rodríguez CE, Song Y, Chan JM, Zhang Y, Odeh S, Kosztowski T, Leon-Rossell A, Concepción JL, Yardley V, Croft SL, Urbina JA, Oldfield E.
J Med Chem (2006) 49 : 215 -223
PubMed 16392806 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 32 5.13 6.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL52621 1 6.00
CHEMBL53982 1 5.70
CHEMBL199858 1 5.70
CHEMBL125461 1 5.70
CHEMBL199439 1 5.70
CHEMBL200335 1 5.70
CHEMBL370377 1 5.52
CHEMBL199310 1 5.52
CHEMBL55140 1 5.52
CHEMBL923 RISEDRONIC ACID 4.0 1 5.52
CHEMBL196726 1 5.52
CHEMBL299717 (PROPYLAMINO)METHYLENEDIPHOSPHONIC ACID 1 5.40
CHEMBL55353 (BUTYL(ETHYL)AMINO)METHYLENEDIPHOSPHONIC ACID 1 5.40
CHEMBL197935 1 5.16
CHEMBL433833 1 5.00
CHEMBL54004 1 5.00
CHEMBL292224 (CYCLOPROPYLAMINO)METHYLENEDIPHOSPHONIC ACID 1 4.52
CHEMBL202390 1 4.52
CHEMBL199978 1 4.28
CHEMBL381465 1 4.21
CHEMBL333503 1 4.12
CHEMBL194800 1 4.11
CHEMBL450938 (3-NITROPHENYLAMINO)METHYLENEDIPHOSPHONIC ACID 1 4.11
CHEMBL197132 1 -
CHEMBL196676 1 -
CHEMBL443750 1 -
CHEMBL55886 1 -
CHEMBL198409 1 -
CHEMBL55371 1 -
CHEMBL438976 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL52621 IC50 = 1000.0 nM 6.00
CHEMBL53982 IC50 = 2000.0 nM 5.70
CHEMBL200335 IC50 = 2000.0 nM 5.70
CHEMBL199439 IC50 = 2000.0 nM 5.70
CHEMBL125461 IC50 = 2000.0 nM 5.70
CHEMBL199858 IC50 = 2000.0 nM 5.70
CHEMBL370377 IC50 = 3000.0 nM 5.52
CHEMBL199310 IC50 = 3000.0 nM 5.52
CHEMBL55140 IC50 = 3000.0 nM 5.52
CHEMBL923 RISEDRONIC ACID IC50 = 3000.0 nM 5.52
CHEMBL196726 IC50 = 3000.0 nM 5.52
CHEMBL299717 (PROPYLAMINO)METHYLENEDIPHOSPHONIC ACID IC50 = 4000.0 nM 5.40
CHEMBL55353 (BUTYL(ETHYL)AMINO)METHYLENEDIPHOSPHONIC ACID IC50 = 4000.0 nM 5.40
CHEMBL197935 IC50 = 7000.0 nM 5.16
CHEMBL54004 IC50 = 10000.0 nM 5.00
CHEMBL433833 IC50 = 10000.0 nM 5.00
CHEMBL292224 (CYCLOPROPYLAMINO)METHYLENEDIPHOSPHONIC ACID IC50 = 30000.0 nM 4.52
CHEMBL202390 IC50 = 30000.0 nM 4.52
CHEMBL199978 IC50 = 52000.0 nM 4.28
CHEMBL381465 IC50 = 62000.0 nM 4.21
CHEMBL333503 IC50 = 75000.0 nM 4.12
CHEMBL194800 IC50 = 77000.0 nM 4.11
CHEMBL450938 (3-NITROPHENYLAMINO)METHYLENEDIPHOSPHONIC ACID IC50 = 78000.0 nM 4.11
CHEMBL197132 IC50 = 889000.0 nM -
CHEMBL196676 IC50 = 103000.0 nM -
CHEMBL443750 IC50 = 351000.0 nM -
CHEMBL55886 IC50 - -
CHEMBL198409 IC50 = 253000.0 nM -
CHEMBL55371 IC50 = 211000.0 nM -
CHEMBL438976 IC50 = 122000.0 nM -
CHEMBL370662 IC50 = 112000.0 nM -
CHEMBL200262 IC50 = 2052000.0 nM -