Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL865780

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory activity against Trypanosoma cruzi hexokinase
ChEMBL ↗
82
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Trypanosoma cruzi
Confidence 9 — Direct single protein target
Curated By Expert

Target

Hexokinase (CHEMBL4151) ↗
Type SINGLE PROTEIN
Organism Trypanosoma cruzi

Publication

Inhibition of Trypanosoma cruzi hexokinase by bisphosphonates.
Hudock MP, Sanz-Rodríguez CE, Song Y, Chan JM, Zhang Y, Odeh S, Kosztowski T, Leon-Rossell A, Concepción JL, Yardley V, Croft SL, Urbina JA, Oldfield E.
J Med Chem (2006) 49 : 215 -223
PubMed 16392806 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 82 5.43 6.09

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL200262 — — 2 6.09
CHEMBL370662 — — 2 6.02
CHEMBL433833 — — 2 5.84
CHEMBL438976 — — 2 5.74
CHEMBL55371 — — 2 5.71
CHEMBL200335 — — 2 5.64
CHEMBL200107 — — 2 5.64
CHEMBL450938 (3-NITROPHENYLAMINO)METHYLENEDIPHOSPHONIC ACID — 2 5.62
CHEMBL194800 — — 2 5.56
CHEMBL54004 — — 2 5.56
CHEMBL381465 — — 2 5.46
CHEMBL202878 — — 2 5.44
CHEMBL198409 — — 2 5.39
CHEMBL55886 — — 2 4.90
CHEMBL443750 — — 2 4.83
CHEMBL196676 — — 2 4.46
CHEMBL55140 — — 2 4.34
CHEMBL125461 — — 1 -
CHEMBL199978 — — 1 -
CHEMBL923 RISEDRONIC ACID 4.0 2 -
CHEMBL202390 — — 2 -
CHEMBL200029 — — 2 -
CHEMBL197935 — — 2 -
CHEMBL199439 — — 2 -
CHEMBL292224 (CYCLOPROPYLAMINO)METHYLENEDIPHOSPHONIC ACID — 2 -
CHEMBL299717 (PROPYLAMINO)METHYLENEDIPHOSPHONIC ACID — 2 -
CHEMBL370377 — — 2 -
CHEMBL55353 (BUTYL(ETHYL)AMINO)METHYLENEDIPHOSPHONIC ACID — 2 -
CHEMBL53982 — — 2 -
CHEMBL52621 — — 2 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL200262 — IC50 = 812.83 nM 6.09
CHEMBL200262 — IC50 = 810.0 nM 6.09
CHEMBL370662 — IC50 = 954.99 nM 6.02
CHEMBL370662 — IC50 = 950.0 nM 6.02
CHEMBL433833 — IC50 = 1445.44 nM 5.84
CHEMBL433833 — IC50 = 1450.0 nM 5.84
CHEMBL438976 — IC50 = 1819.7 nM 5.74
CHEMBL438976 — IC50 = 1820.0 nM 5.74
CHEMBL55371 — IC50 = 1949.84 nM 5.71
CHEMBL55371 — IC50 = 1950.0 nM 5.71
CHEMBL200335 — IC50 = 2290.0 nM 5.64
CHEMBL200335 — IC50 = 2290.87 nM 5.64
CHEMBL200107 — IC50 = 2290.0 nM 5.64
CHEMBL200107 — IC50 = 2290.87 nM 5.64
CHEMBL450938 (3-NITROPHENYLAMINO)METHYLENEDIPHOSPHONIC ACID IC50 = 2398.83 nM 5.62
CHEMBL450938 (3-NITROPHENYLAMINO)METHYLENEDIPHOSPHONIC ACID IC50 = 2400.0 nM 5.62
CHEMBL54004 — IC50 = 2754.23 nM 5.56
CHEMBL194800 — IC50 = 2754.23 nM 5.56
CHEMBL54004 — IC50 = 2750.0 nM 5.56
CHEMBL194800 — IC50 = 2750.0 nM 5.56
CHEMBL381465 — IC50 = 3470.0 nM 5.46
CHEMBL381465 — IC50 = 3467.37 nM 5.46
CHEMBL202878 — IC50 = 3630.78 nM 5.44
CHEMBL202878 — IC50 = 3630.0 nM 5.44
CHEMBL198409 — IC50 = 4070.0 nM 5.39
CHEMBL198409 — IC50 = 4073.8 nM 5.39
CHEMBL55886 — IC50 = 12589.25 nM 4.90
CHEMBL55886 — IC50 = 12600.0 nM 4.90
CHEMBL443750 — IC50 = 14791.08 nM 4.83
CHEMBL443750 — IC50 = 14800.0 nM 4.83
CHEMBL196676 — IC50 = 34673.69 nM 4.46
CHEMBL196676 — IC50 = 34700.0 nM 4.46
CHEMBL55140 — IC50 = 45740.0 nM 4.34
CHEMBL55140 — IC50 = 45708.82 nM 4.34
CHEMBL199439 — IC50 = 301995.17 nM -
CHEMBL333503 — IC50 = 301995.17 nM -
CHEMBL191613 2,4-DICHLOROPHENYLAMINOMETHYLENEBISPHOSPHONIC ACID IC50 = 301995.17 nM -
CHEMBL52621 — IC50 = 301995.17 nM -
CHEMBL53982 — IC50 = 301995.17 nM -
CHEMBL55353 (BUTYL(ETHYL)AMINO)METHYLENEDIPHOSPHONIC ACID IC50 = 301995.17 nM -
CHEMBL370377 — IC50 = 301995.17 nM -
CHEMBL299717 (PROPYLAMINO)METHYLENEDIPHOSPHONIC ACID IC50 = 301995.17 nM -
CHEMBL292224 (CYCLOPROPYLAMINO)METHYLENEDIPHOSPHONIC ACID IC50 = 301995.17 nM -
CHEMBL199652 — IC50 >= 300000.0 nM -
CHEMBL197935 — IC50 = 301995.17 nM -
CHEMBL199654 — IC50 = 301995.17 nM -
CHEMBL200720 — IC50 = 301995.17 nM -
CHEMBL125461 — IC50 >= 300000.0 nM -
CHEMBL199978 — IC50 >= 300000.0 nM -
CHEMBL202390 — IC50 = 301995.17 nM -