Assay Detail
Binding
CHEMBL865873
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against recombinant human PTP1B
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
PTP-1B inhibitors: cyclopenta[d][1,2]-oxazine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.67 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL200117 | — | — | 1 | 6.85 |
| CHEMBL371026 | — | — | 1 | 6.57 |
| CHEMBL201662 | — | — | 1 | 6.10 |
| CHEMBL201161 | — | — | 1 | 5.79 |
| CHEMBL371322 | — | — | 1 | 5.71 |
| CHEMBL202197 | — | — | 1 | 5.67 |
| CHEMBL201909 | — | — | 1 | 5.47 |
| CHEMBL370140 | — | — | 1 | 5.26 |
| CHEMBL370584 | — | — | 1 | 5.25 |
| CHEMBL202573 | — | — | 1 | 5.12 |
| CHEMBL199479 | — | — | 1 | 5.11 |
| CHEMBL202219 | — | — | 1 | 5.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL200117 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL371026 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL201662 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL201161 | — | IC50 | = | 1640.0 | nM | 5.79 |
| CHEMBL371322 | — | IC50 | = | 1960.0 | nM | 5.71 |
| CHEMBL202197 | — | IC50 | = | 2160.0 | nM | 5.67 |
| CHEMBL201909 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL370140 | — | IC50 | = | 5480.0 | nM | 5.26 |
| CHEMBL370584 | — | IC50 | = | 5630.0 | nM | 5.25 |
| CHEMBL202573 | — | IC50 | = | 7550.0 | nM | 5.12 |
| CHEMBL199479 | — | IC50 | = | 7820.0 | nM | 5.11 |
| CHEMBL202219 | — | IC50 | = | 8190.0 | nM | 5.09 |