Assay Detail
Binding
CHEMBL866014
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Inhibition of JNK3
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery of potent, highly selective, and orally bioavailable pyridine carboxamide c-Jun NH2-terminal kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.19 | 7.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL377408 | — | — | 1 | 7.43 |
| CHEMBL424872 | — | — | 1 | 7.22 |
| CHEMBL377383 | — | — | 1 | 6.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL377408 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL424872 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL377383 | — | IC50 | = | 120.0 | nM | 6.92 |