Assay Detail
Binding
CHEMBL866102
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Inhibition of human cathepsin S
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design and synthesis of tetracyclic nonpeptidic biaryl nitrile inhibitors of cathepsin K.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 5.37 | 5.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL184514 | — | — | 1 | 5.77 |
| CHEMBL213930 | — | — | 1 | 5.75 |
| CHEMBL213244 | — | — | 1 | 5.44 |
| CHEMBL212907 | — | — | 1 | 5.25 |
| CHEMBL212879 | — | — | 1 | 5.25 |
| CHEMBL213194 | — | — | 1 | 5.13 |
| CHEMBL211737 | — | — | 1 | 5.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL184514 | — | Ki | = | 1695.0 | nM | 5.77 |
| CHEMBL213930 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL213244 | — | Ki | = | 3600.0 | nM | 5.44 |
| CHEMBL212907 | — | Ki | = | 5600.0 | nM | 5.25 |
| CHEMBL212879 | — | Ki | = | 5600.0 | nM | 5.25 |
| CHEMBL213194 | — | Ki | = | 7400.0 | nM | 5.13 |
| CHEMBL211737 | — | Ki | = | 9500.0 | nM | 5.02 |