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Assay Detail

CHEMBL866355

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Functional
Agonist activity in Xenopus laevis melanophore assessed as potency for pigment aggregation
27
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Xenopus laevis
Cell Type Melanophore
Confidence 1 — Organism
Curated By Expert

Target

Melanophore (CHEMBL614313)
Type CELL-LINE
Organism Xenopus laevis

Publication

Mapping the melatonin receptor. 7. Subtype selective ligands based on beta-substituted N-acyl-5-methoxytryptamines and beta-substituted N-acyl-5-methoxy-1-methyltryptamines.
Tsotinis A, Vlachou M, Papahatjis DP, Calogeropoulou T, Nikas SP, Garratt PJ, Piccio V, Vonhoff S, Davidson K, Teh MT, Sugden D.
J Med Chem (2006) 49 : 3509 -3519
PubMed 16759094 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 27 8.45 10.31

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL210147 1 10.31
CHEMBL45 MELATONIN 4.0 1 10.20
CHEMBL210791 3 9.01
CHEMBL377101 1 9.00
CHEMBL207420 1 9.00
CHEMBL207745 1 9.00
CHEMBL426127 1 8.90
CHEMBL207960 1 8.78
CHEMBL209712 1 8.77
CHEMBL207625 1 8.70
CHEMBL207676 1 8.59
CHEMBL379616 1 8.43
CHEMBL208307 1 8.20
CHEMBL377871 1 8.17
CHEMBL209711 1 7.98
CHEMBL382439 1 7.24
CHEMBL424693 1 6.01
CHEMBL379413 1 6.00
CHEMBL382050 1 -
CHEMBL379504 1 -
CHEMBL426861 1 -
CHEMBL379096 1 -
CHEMBL206472 1 -
CHEMBL208802 1 -
CHEMBL206686 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL210147 EC50 = 0.049 nM 10.31
CHEMBL45 MELATONIN EC50 = 0.063 nM 10.20
CHEMBL210791 EC50 = 0.98 nM 9.01
CHEMBL377101 EC50 = 1.0 nM 9.00
CHEMBL207420 EC50 = 0.99 nM 9.00
CHEMBL207745 EC50 = 1.0 nM 9.00
CHEMBL426127 EC50 = 1.26 nM 8.90
CHEMBL207960 EC50 = 1.67 nM 8.78
CHEMBL209712 EC50 = 1.7 nM 8.77
CHEMBL210791 EC50 = 1.72 nM 8.76
CHEMBL207625 EC50 = 2.0 nM 8.70
CHEMBL207676 EC50 = 2.56 nM 8.59
CHEMBL379616 EC50 = 3.72 nM 8.43
CHEMBL208307 EC50 = 6.31 nM 8.20
CHEMBL377871 EC50 = 6.8 nM 8.17
CHEMBL209711 EC50 = 10.5 nM 7.98
CHEMBL210791 EC50 = 10.8 nM 7.97
CHEMBL382439 EC50 = 57.5 nM 7.24
CHEMBL424693 EC50 = 980.0 nM 6.01
CHEMBL379413 EC50 = 1010.0 nM 6.00
CHEMBL382050 EC50 - -
CHEMBL379504 EC50 - -
CHEMBL426861 EC50 - -
CHEMBL379096 EC50 - -
CHEMBL206472 EC50 = 0.0072 nM -
CHEMBL208802 EC50 - -
CHEMBL206686 EC50 - -