Assay Detail
Functional
CHEMBL866363
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Antiproliferative activity against human taxol resistant CCRF-CEM cell line
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Potent antitumor 9-anilinoacridines and acridines bearing an alkylating N-mustard residue on the acridine chromophore: synthesis and biological activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 7.07 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL210758 | — | — | 1 | 7.66 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.54 |
| CHEMBL182739 | — | — | 1 | 7.47 |
| CHEMBL209414 | — | — | 1 | 7.39 |
| CHEMBL378694 | — | — | 1 | 7.36 |
| CHEMBL377262 | — | — | 1 | 7.33 |
| CHEMBL379854 | — | — | 1 | 7.30 |
| CHEMBL210473 | — | — | 1 | 7.24 |
| CHEMBL379924 | — | — | 1 | 7.24 |
| CHEMBL210696 | — | — | 1 | 7.21 |
| CHEMBL207565 | — | — | 1 | 7.20 |
| CHEMBL210202 | — | — | 1 | 7.05 |
| CHEMBL378138 | — | — | 1 | 6.93 |
| CHEMBL211010 | — | — | 1 | 6.93 |
| CHEMBL209234 | — | — | 1 | 6.90 |
| CHEMBL377962 | — | — | 1 | 6.86 |
| CHEMBL377060 | — | — | 1 | 6.82 |
| CHEMBL209349 | — | — | 1 | 6.41 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 6.32 |
| CHEMBL321473 | — | — | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL210758 | — | IC50 | = | 21.7 | nM | 7.66 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 28.7 | nM | 7.54 |
| CHEMBL182739 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL209414 | — | IC50 | = | 40.5 | nM | 7.39 |
| CHEMBL378694 | — | IC50 | = | 43.9 | nM | 7.36 |
| CHEMBL377262 | — | IC50 | = | 46.5 | nM | 7.33 |
| CHEMBL379854 | — | IC50 | = | 49.8 | nM | 7.30 |
| CHEMBL210473 | — | IC50 | = | 57.5 | nM | 7.24 |
| CHEMBL379924 | — | IC50 | = | 57.8 | nM | 7.24 |
| CHEMBL210696 | — | IC50 | = | 61.1 | nM | 7.21 |
| CHEMBL207565 | — | IC50 | = | 63.3 | nM | 7.20 |
| CHEMBL210202 | — | IC50 | = | 89.9 | nM | 7.05 |
| CHEMBL378138 | — | IC50 | = | 117.0 | nM | 6.93 |
| CHEMBL211010 | — | IC50 | = | 117.0 | nM | 6.93 |
| CHEMBL209234 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL377962 | — | IC50 | = | 139.0 | nM | 6.86 |
| CHEMBL377060 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL209349 | — | IC50 | = | 393.0 | nM | 6.41 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 484.3 | nM | 6.32 |
| CHEMBL321473 | — | IC50 | = | 600.0 | nM | 6.22 |