Assay Detail
Functional
CHEMBL866364
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human vinblastine resistant CCRF-CEM cell line
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Potent antitumor 9-anilinoacridines and acridines bearing an alkylating N-mustard residue on the acridine chromophore: synthesis and biological activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.94 | 8.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL182739 | — | — | 1 | 8.12 |
| CHEMBL210758 | — | — | 1 | 7.73 |
| CHEMBL377262 | — | — | 1 | 7.51 |
| CHEMBL379924 | — | — | 1 | 7.37 |
| CHEMBL379854 | — | — | 1 | 7.33 |
| CHEMBL378694 | — | — | 1 | 7.29 |
| CHEMBL210696 | — | — | 1 | 7.26 |
| CHEMBL210473 | — | — | 1 | 7.22 |
| CHEMBL210202 | — | — | 1 | 7.06 |
| CHEMBL209414 | — | — | 1 | 6.96 |
| CHEMBL207565 | — | — | 1 | 6.90 |
| CHEMBL377962 | — | — | 1 | 6.82 |
| CHEMBL378138 | — | — | 1 | 6.79 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 6.68 |
| CHEMBL209234 | — | — | 1 | 6.64 |
| CHEMBL377060 | — | — | 1 | 6.60 |
| CHEMBL209349 | — | — | 1 | 6.51 |
| CHEMBL211010 | — | — | 1 | 6.47 |
| CHEMBL321473 | — | — | 1 | 5.80 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 5.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL182739 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL210758 | — | IC50 | = | 18.8 | nM | 7.73 |
| CHEMBL377262 | — | IC50 | = | 31.2 | nM | 7.51 |
| CHEMBL379924 | — | IC50 | = | 42.3 | nM | 7.37 |
| CHEMBL379854 | — | IC50 | = | 46.9 | nM | 7.33 |
| CHEMBL378694 | — | IC50 | = | 51.3 | nM | 7.29 |
| CHEMBL210696 | — | IC50 | = | 54.5 | nM | 7.26 |
| CHEMBL210473 | — | IC50 | = | 60.1 | nM | 7.22 |
| CHEMBL210202 | — | IC50 | = | 86.5 | nM | 7.06 |
| CHEMBL209414 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL207565 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL377962 | — | IC50 | = | 152.0 | nM | 6.82 |
| CHEMBL378138 | — | IC50 | = | 163.0 | nM | 6.79 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 206.6 | nM | 6.68 |
| CHEMBL209234 | — | IC50 | = | 231.0 | nM | 6.64 |
| CHEMBL377060 | — | IC50 | = | 253.0 | nM | 6.60 |
| CHEMBL209349 | — | IC50 | = | 308.0 | nM | 6.51 |
| CHEMBL211010 | — | IC50 | = | 338.0 | nM | 6.47 |
| CHEMBL321473 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 1731.0 | nM | 5.76 |