Assay Detail
Functional
CHEMBL866366
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Antiproliferative activity against human HCT116 cell line
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Potent antitumor 9-anilinoacridines and acridines bearing an alkylating N-mustard residue on the acridine chromophore: synthesis and biological activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 7.76 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 9.15 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.82 |
| CHEMBL182739 | — | — | 1 | 8.26 |
| CHEMBL207565 | — | — | 1 | 8.11 |
| CHEMBL210202 | — | — | 1 | 8.08 |
| CHEMBL377262 | — | — | 1 | 8.05 |
| CHEMBL210696 | — | — | 1 | 8.04 |
| CHEMBL211010 | — | — | 1 | 8.04 |
| CHEMBL209414 | — | — | 1 | 8.02 |
| CHEMBL379924 | — | — | 1 | 7.87 |
| CHEMBL378694 | — | — | 1 | 7.86 |
| CHEMBL210758 | — | — | 1 | 7.63 |
| CHEMBL210473 | — | — | 1 | 7.32 |
| CHEMBL379854 | — | — | 1 | 7.27 |
| CHEMBL209234 | — | — | 1 | 7.22 |
| CHEMBL378138 | — | — | 1 | 7.02 |
| CHEMBL209349 | — | — | 1 | 6.93 |
| CHEMBL377962 | — | — | 1 | 6.90 |
| CHEMBL377060 | — | — | 1 | 6.87 |
| CHEMBL321473 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL182739 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL207565 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL210202 | — | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL377262 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL210696 | — | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL211010 | — | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL209414 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL379924 | — | IC50 | = | 13.6 | nM | 7.87 |
| CHEMBL378694 | — | IC50 | = | 13.8 | nM | 7.86 |
| CHEMBL210758 | — | IC50 | = | 23.2 | nM | 7.63 |
| CHEMBL210473 | — | IC50 | = | 48.2 | nM | 7.32 |
| CHEMBL379854 | — | IC50 | = | 53.8 | nM | 7.27 |
| CHEMBL209234 | — | IC50 | = | 59.5 | nM | 7.22 |
| CHEMBL378138 | — | IC50 | = | 94.9 | nM | 7.02 |
| CHEMBL209349 | — | IC50 | = | 117.5 | nM | 6.93 |
| CHEMBL377962 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL377060 | — | IC50 | = | 135.4 | nM | 6.87 |
| CHEMBL321473 | — | IC50 | - | — | - |