Assay Detail
Binding
CHEMBL866541
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human TR-alpha-1 by radioligand binding assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Thyroid receptor ligands. Part 5: novel bicyclic agonist ligands selective for the thyroid hormone receptor beta.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.43 | 9.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL557 | DETROTHYRONINE | 2.0 | 1 | 9.62 |
| CHEMBL203777 | — | — | 1 | 8.85 |
| CHEMBL425939 | — | — | 1 | 8.60 |
| CHEMBL203828 | — | — | 1 | 7.42 |
| CHEMBL203555 | — | — | 1 | 6.70 |
| CHEMBL378593 | — | — | 1 | 6.60 |
| CHEMBL251439 | — | — | 1 | 6.21 |
| CHEMBL250880 | — | — | 1 | 5.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL557 | DETROTHYRONINE | IC50 | = | 0.24 | nM | 9.62 |
| CHEMBL203777 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL425939 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL203828 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL203555 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL378593 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL251439 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL250880 | — | IC50 | = | 3500.0 | nM | 5.46 |