Assay Detail
Binding
CHEMBL866557
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Binding affinity to MC3 receptor
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis of Tic-D-Phe Psi[CH2-CH2] isostere and its use in the development of melanocortin receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 5.64 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL380120 | — | — | 1 | 7.64 |
| CHEMBL380437 | — | — | 1 | 6.42 |
| CHEMBL206033 | — | — | 1 | 6.33 |
| CHEMBL381357 | — | — | 1 | 5.79 |
| CHEMBL202699 | — | — | 1 | 5.76 |
| CHEMBL383256 | — | — | 1 | 5.62 |
| CHEMBL437132 | — | — | 1 | 5.21 |
| CHEMBL206018 | — | — | 1 | 4.74 |
| CHEMBL444883 | — | — | 1 | 4.61 |
| CHEMBL203252 | — | — | 1 | 4.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL380120 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL380437 | — | Ki | = | 382.0 | nM | 6.42 |
| CHEMBL206033 | — | Ki | = | 468.0 | nM | 6.33 |
| CHEMBL381357 | — | Ki | = | 1632.0 | nM | 5.79 |
| CHEMBL202699 | — | Ki | = | 1727.0 | nM | 5.76 |
| CHEMBL383256 | — | Ki | = | 2411.0 | nM | 5.62 |
| CHEMBL437132 | — | Ki | = | 6198.0 | nM | 5.21 |
| CHEMBL206018 | — | Ki | = | 18016.0 | nM | 4.74 |
| CHEMBL444883 | — | Ki | = | 24689.0 | nM | 4.61 |
| CHEMBL203252 | — | Ki | = | 55474.0 | nM | 4.26 |