Assay Detail
Binding
CHEMBL866558
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Binding affinity to MC4 receptor
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis of Tic-D-Phe Psi[CH2-CH2] isostere and its use in the development of melanocortin receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.33 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL437132 | — | — | 1 | 8.30 |
| CHEMBL380120 | — | — | 1 | 8.00 |
| CHEMBL206033 | — | — | 1 | 7.89 |
| CHEMBL381357 | — | — | 1 | 7.62 |
| CHEMBL203252 | — | — | 1 | 7.43 |
| CHEMBL380437 | — | — | 1 | 7.12 |
| CHEMBL202699 | — | — | 1 | 6.98 |
| CHEMBL206018 | — | — | 1 | 6.67 |
| CHEMBL444883 | — | — | 1 | 6.67 |
| CHEMBL383256 | — | — | 1 | 6.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL437132 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL380120 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL206033 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL381357 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL203252 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL380437 | — | Ki | = | 76.0 | nM | 7.12 |
| CHEMBL202699 | — | Ki | = | 104.0 | nM | 6.98 |
| CHEMBL206018 | — | Ki | = | 214.0 | nM | 6.67 |
| CHEMBL444883 | — | Ki | = | 214.0 | nM | 6.67 |
| CHEMBL383256 | — | Ki | = | 220.0 | nM | 6.66 |