Assay Detail
Binding
CHEMBL866567
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Inhibitory activity against VEGFR-2 using 2 uM ATP by HTRF assay
49
Total Activities
46
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
2-((1H-Azol-1-yl)methyl)-N-arylbenzamides: novel dual inhibitors of VEGFR-1/2 kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 43 | 6.69 | 7.82 |
| Activity | 6 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL202011 | — | — | 1 | 7.82 |
| CHEMBL24828 | VANDETANIB | 4.0 | 1 | 7.66 |
| CHEMBL153843 | — | — | 1 | 7.50 |
| CHEMBL382855 | — | — | 1 | 7.33 |
| CHEMBL203965 | — | — | 1 | 7.28 |
| CHEMBL101253 | VATALANIB | 3.0 | 1 | 7.27 |
| CHEMBL205984 | — | — | 1 | 7.25 |
| CHEMBL380932 | — | — | 1 | 7.21 |
| CHEMBL204548 | — | — | 1 | 7.18 |
| CHEMBL205610 | — | — | 1 | 7.14 |
| CHEMBL203243 | — | — | 1 | 7.06 |
| CHEMBL203003 | — | — | 1 | 7.04 |
| CHEMBL205413 | — | — | 1 | 7.02 |
| CHEMBL204099 | — | — | 1 | 6.96 |
| CHEMBL425587 | — | — | 1 | 6.89 |
| CHEMBL206279 | — | — | 1 | 6.68 |
| CHEMBL206403 | — | — | 1 | 6.68 |
| CHEMBL203167 | — | — | 1 | 6.64 |
| CHEMBL377081 | — | — | 1 | 6.55 |
| CHEMBL206348 | — | — | 1 | 6.54 |
| CHEMBL437889 | — | — | 1 | 6.51 |
| CHEMBL202643 | — | — | 1 | 6.46 |
| CHEMBL382584 | — | — | 1 | 6.42 |
| CHEMBL203063 | — | — | 1 | 6.36 |
| CHEMBL206185 | — | — | 1 | 6.36 |
| CHEMBL202805 | — | — | 1 | 6.33 |
| CHEMBL382478 | — | — | 1 | 6.16 |
| CHEMBL380503 | — | — | 1 | 5.81 |
| CHEMBL203429 | — | — | 1 | 5.67 |
| CHEMBL381603 | — | — | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL202011 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL24828 | VANDETANIB | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL153843 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL382855 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL203965 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL101253 | VATALANIB | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL205984 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL380932 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL204548 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL205610 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL203243 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL203003 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL205413 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL204099 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL425587 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL206279 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL206403 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL203167 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL377081 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL206348 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL437889 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL202643 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL382584 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL206185 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL203063 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL202805 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL382478 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL380503 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL203429 | — | IC50 | = | 2120.0 | nM | 5.67 |
| CHEMBL381603 | — | IC50 | = | 2660.0 | nM | 5.58 |
| CHEMBL206567 | — | IC50 | = | 3550.0 | nM | 5.45 |
| CHEMBL202682 | — | IC50 | = | 4280.0 | nM | 5.37 |
| CHEMBL205876 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL381786 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL206388 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL379888 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL382256 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL206215 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL205401 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL377952 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL205282 | — | Activity | - | — | - | |
| CHEMBL205649 | — | Activity | - | — | - | |
| CHEMBL382596 | — | Activity | - | — | - | |
| CHEMBL382596 | — | IC50 | - | — | - | |
| CHEMBL203110 | — | Activity | - | — | - | |
| CHEMBL203110 | — | IC50 | - | — | - | |
| CHEMBL205138 | — | Activity | - | — | - | |
| CHEMBL205138 | — | IC50 | - | — | - | |
| CHEMBL383267 | — | Activity | - | — | - |