Compound Detail
CHEMBL381603
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Basic Information
| ChEMBL ID | CHEMBL381603 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JNJLFISRSZHOHY-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
358.8
MW (Da)
5.28
ALogP
3
HBA
1
HBD
46.5
PSA (Ų)
0.48
QED
1
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.58
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 5.58 | 5.58 | 2660.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 | IC50 | = | 2660.0 | nM | 5.58 | Inhibitory activity against VEGFR-2 using 2 uM ATP by HTRF assay | 16364640 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16364640 | 10.1016/j.bmcl.2005.11.105 | Vascular endothelial growth factor receptor 2 | 1 |
Data from ChEMBL 36 via Core Engine