Assay Detail
Functional
CHEMBL866598
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 HXB2 in MT4 cells
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Ultra-potent P1 modified arylsulfonamide HIV protease inhibitors: the discovery of GW0385.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 8.20 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL438958 | — | — | 1 | 9.22 |
| CHEMBL206031 | BRECANAVIR | 2.0 | 1 | 9.15 |
| CHEMBL378247 | — | — | 1 | 9.05 |
| CHEMBL205746 | — | — | 1 | 8.96 |
| CHEMBL208106 | — | — | 1 | 8.92 |
| CHEMBL381368 | — | — | 1 | 8.92 |
| CHEMBL379921 | — | — | 1 | 8.92 |
| CHEMBL204924 | — | — | 1 | 8.89 |
| CHEMBL381615 | — | — | 1 | 8.80 |
| CHEMBL380741 | — | — | 1 | 8.72 |
| CHEMBL407940 | — | — | 1 | 8.68 |
| CHEMBL380203 | — | — | 1 | 8.64 |
| CHEMBL380495 | — | — | 1 | 8.60 |
| CHEMBL379982 | — | — | 1 | 8.55 |
| CHEMBL380494 | — | — | 1 | 8.51 |
| CHEMBL381124 | — | — | 1 | 8.48 |
| CHEMBL208119 | — | — | 1 | 8.43 |
| CHEMBL1323 | DARUNAVIR | 4.0 | 1 | 8.41 |
| CHEMBL205549 | — | — | 1 | 8.33 |
| CHEMBL383481 | — | — | 1 | 8.24 |
| CHEMBL207623 | — | — | 1 | 8.21 |
| CHEMBL378369 | — | — | 1 | 8.14 |
| CHEMBL382495 | — | — | 1 | 8.12 |
| CHEMBL376944 | — | — | 1 | 8.02 |
| CHEMBL205420 | — | — | 1 | 7.96 |
| CHEMBL205621 | — | — | 1 | 7.70 |
| CHEMBL380593 | — | — | 1 | 7.68 |
| CHEMBL1163 | ATAZANAVIR | 4.0 | 1 | 7.60 |
| CHEMBL729 | LOPINAVIR | 4.0 | 1 | 7.40 |
| CHEMBL5483011 | INDINAVIR | 3.0 | 1 | 7.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL438958 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL206031 | BRECANAVIR | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL378247 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL205746 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL208106 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL381368 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL379921 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL204924 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL381615 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL380741 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL407940 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL380203 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL380495 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL379982 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL380494 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL381124 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL208119 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL1323 | DARUNAVIR | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL205549 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL383481 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL207623 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL378369 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL382495 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL376944 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL205420 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL205621 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL380593 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL1163 | ATAZANAVIR | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL729 | LOPINAVIR | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5483011 | INDINAVIR | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL114 | SAQUINAVIR | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL207843 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL116 | AMPRENAVIR | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL163 | RITONAVIR | IC50 | = | 268.0 | nM | 6.57 |
| CHEMBL584 | NELFINAVIR | IC50 | = | 320.0 | nM | 6.50 |