Assay Detail
Binding
CHEMBL866709
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Inhibition of rat microsomal 17,20-lyase component of P450-17alpha
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Steroid 17-alpha-hydroxylase/17,20 lyase (CHEMBL4430) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and biochemical evaluation of a range of potent benzyl imidazole-based compounds as potential inhibitors of the enzyme complex 17alpha-hydroxylase/17,20-lyase (P450(17alpha)).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.20 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL427399 | — | — | 1 | 5.80 |
| CHEMBL157101 | KETOCONAZOLE | 4.0 | 1 | 5.78 |
| CHEMBL379436 | — | — | 1 | 5.68 |
| CHEMBL441367 | — | — | 1 | 5.55 |
| CHEMBL211276 | — | — | 1 | 5.50 |
| CHEMBL210125 | — | — | 1 | 5.48 |
| CHEMBL211207 | — | — | 1 | 5.17 |
| CHEMBL13784 | — | — | 1 | 5.14 |
| CHEMBL349822 | — | — | 1 | 5.12 |
| CHEMBL166845 | — | — | 1 | 5.08 |
| CHEMBL212741 | — | — | 1 | 5.05 |
| CHEMBL373588 | — | — | 1 | 5.02 |
| CHEMBL446946 | — | — | 1 | 4.93 |
| CHEMBL377770 | — | — | 1 | 4.73 |
| CHEMBL213596 | — | — | 1 | 4.71 |
| CHEMBL14192 | BENZYLIMIDAZOLE | — | 1 | 4.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL427399 | — | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL157101 | KETOCONAZOLE | IC50 | = | 1660.0 | nM | 5.78 |
| CHEMBL379436 | — | IC50 | = | 2070.0 | nM | 5.68 |
| CHEMBL441367 | — | IC50 | = | 2810.0 | nM | 5.55 |
| CHEMBL211276 | — | IC50 | = | 3160.0 | nM | 5.50 |
| CHEMBL210125 | — | IC50 | = | 3340.0 | nM | 5.48 |
| CHEMBL211207 | — | IC50 | = | 6760.0 | nM | 5.17 |
| CHEMBL13784 | — | IC50 | = | 7170.0 | nM | 5.14 |
| CHEMBL349822 | — | IC50 | = | 7670.0 | nM | 5.12 |
| CHEMBL166845 | — | IC50 | = | 8220.0 | nM | 5.08 |
| CHEMBL212741 | — | IC50 | = | 8810.0 | nM | 5.05 |
| CHEMBL373588 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL446946 | — | IC50 | = | 11800.0 | nM | 4.93 |
| CHEMBL377770 | — | IC50 | = | 18440.0 | nM | 4.73 |
| CHEMBL213596 | — | IC50 | = | 19460.0 | nM | 4.71 |
| CHEMBL14192 | BENZYLIMIDAZOLE | IC50 | = | 39060.0 | nM | 4.41 |