Assay Detail
Functional
CHEMBL866792
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Inhibition of glucose-stimulated insulin release in Wistar rat islets
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
New 3-alkylamino-4H-thieno-1,2,4-thiadiazine 1,1-dioxide derivatives activate ATP-sensitive potassium channels of pancreatic beta cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 6.71 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL210749 | — | — | 1 | 7.70 |
| CHEMBL212041 | — | — | 1 | 7.40 |
| CHEMBL379292 | — | — | 1 | 6.96 |
| CHEMBL212479 | — | — | 1 | 6.80 |
| CHEMBL135191 | TIFENAZOXIDE | 2.0 | 1 | 6.68 |
| CHEMBL181 | DIAZOXIDE | 4.0 | 1 | 4.69 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL210749 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL212041 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL379292 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL212479 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL135191 | TIFENAZOXIDE | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL181 | DIAZOXIDE | EC50 | = | 20280.0 | nM | 4.69 |