Assay Detail
Functional
CHEMBL866796
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Inhibition of glucose-stimulated insulin release in betaTC6 cells
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Beta-TC6 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
New 3-alkylamino-4H-thieno-1,2,4-thiadiazine 1,1-dioxide derivatives activate ATP-sensitive potassium channels of pancreatic beta cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 20 | 5.88 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL134168 | — | — | 1 | 7.70 |
| CHEMBL445321 | — | — | 1 | 6.82 |
| CHEMBL438967 | — | — | 1 | 6.72 |
| CHEMBL212041 | — | — | 1 | 6.62 |
| CHEMBL135191 | TIFENAZOXIDE | 2.0 | 1 | 6.60 |
| CHEMBL210419 | — | — | 1 | 6.55 |
| CHEMBL210749 | — | — | 1 | 6.51 |
| CHEMBL212476 | — | — | 1 | 6.13 |
| CHEMBL208928 | — | — | 1 | 6.00 |
| CHEMBL212479 | — | — | 1 | 5.85 |
| CHEMBL209313 | — | — | 1 | 5.68 |
| CHEMBL379292 | — | — | 1 | 5.57 |
| CHEMBL210864 | — | — | 1 | 5.45 |
| CHEMBL378871 | — | — | 1 | 5.21 |
| CHEMBL210210 | — | — | 1 | 5.17 |
| CHEMBL210948 | — | — | 1 | 4.89 |
| CHEMBL383992 | — | — | 1 | 4.87 |
| CHEMBL210673 | — | — | 1 | 4.70 |
| CHEMBL181 | DIAZOXIDE | 4.0 | 1 | 4.64 |
| CHEMBL441686 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL134168 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL445321 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL438967 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL212041 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL135191 | TIFENAZOXIDE | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL210419 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL210749 | — | EC50 | = | 310.0 | nM | 6.51 |
| CHEMBL212476 | — | EC50 | = | 740.0 | nM | 6.13 |
| CHEMBL208928 | — | EC50 | = | 990.0 | nM | 6.00 |
| CHEMBL212479 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL209313 | — | EC50 | = | 2070.0 | nM | 5.68 |
| CHEMBL379292 | — | EC50 | = | 2670.0 | nM | 5.57 |
| CHEMBL210864 | — | EC50 | = | 3570.0 | nM | 5.45 |
| CHEMBL378871 | — | EC50 | = | 6110.0 | nM | 5.21 |
| CHEMBL210210 | — | EC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL210948 | — | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL383992 | — | EC50 | = | 13360.0 | nM | 4.87 |
| CHEMBL210673 | — | EC50 | = | 19820.0 | nM | 4.70 |
| CHEMBL181 | DIAZOXIDE | EC50 | = | 22980.0 | nM | 4.64 |
| CHEMBL441686 | — | EC50 | - | — | - |