Assay Detail
Functional
CHEMBL866878
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Potency at CB1 receptor in rat brain by [35S]GTP-gamma-S binding assay
5
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Alpha-methylated derivatives of 2-arachidonoyl glycerol: synthesis, CB1 receptor activity, and enzymatic stability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.15 | 6.00 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL122972 | 2-ARACHIDONOYLGLYCEROL | — | 1 | 6.00 |
| CHEMBL377180 | — | — | 1 | 5.00 |
| CHEMBL381171 | — | — | 1 | 4.80 |
| CHEMBL208282 | — | — | 1 | 4.80 |
| CHEMBL205958 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL122972 | 2-ARACHIDONOYLGLYCEROL | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL377180 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL381171 | — | EC50 | = | 15848.93 | nM | 4.80 |
| CHEMBL208282 | — | EC50 | = | 15848.93 | nM | 4.80 |
| CHEMBL205958 | — | Activity | - | — | - |