Assay Detail
Binding
CHEMBL866913
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Inhibition of human GST-PDE4C
23
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
3',5'-cyclic-AMP phosphodiesterase 4C (CHEMBL291) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Nitrogen-bridged substituted 8-arylquinolines as potent PDE IV inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 8.03 | 10.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL380321 | — | — | 1 | 10.30 |
| CHEMBL206968 | — | — | 1 | 9.05 |
| CHEMBL383225 | — | — | 1 | 9.00 |
| CHEMBL377709 | — | — | 1 | 8.77 |
| CHEMBL382168 | — | — | 1 | 8.77 |
| CHEMBL209295 | — | — | 1 | 8.38 |
| CHEMBL207996 | — | — | 1 | 8.26 |
| CHEMBL380933 | — | — | 1 | 8.23 |
| CHEMBL208100 | — | — | 1 | 8.19 |
| CHEMBL208382 | — | — | 3 | 8.12 |
| CHEMBL378681 | — | — | 1 | 8.02 |
| CHEMBL208236 | — | — | 1 | 7.97 |
| CHEMBL206592 | — | — | 1 | 7.85 |
| CHEMBL379768 | — | — | 1 | 7.77 |
| CHEMBL383837 | — | — | 1 | 7.77 |
| CHEMBL207559 | — | — | 1 | 7.60 |
| CHEMBL208149 | — | — | 1 | 7.58 |
| CHEMBL204522 | — | — | 1 | 7.39 |
| CHEMBL207424 | — | — | 1 | 7.16 |
| CHEMBL207775 | — | — | 1 | 7.01 |
| CHEMBL210840 | — | — | 1 | 6.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL380321 | — | IC50 | = | 0.05 | nM | 10.30 |
| CHEMBL206968 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL383225 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL382168 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL377709 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL209295 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL207996 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL380933 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL208100 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL208382 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL378681 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL208236 | — | IC50 | = | 10.6 | nM | 7.97 |
| CHEMBL208382 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL206592 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL379768 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL383837 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL207559 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL208149 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL204522 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL208382 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL207424 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL207775 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL210840 | — | IC50 | = | 490.0 | nM | 6.31 |