Assay Detail
Functional
CHEMBL867154
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of tubulin polymerization
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Oxadiazole derivatives as a novel class of antimitotic agents: Synthesis, inhibition of tubulin polymerization, and activity in tumor cell lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 5.55 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL203642 | — | — | 1 | 6.30 |
| CHEMBL203755 | — | — | 1 | 6.16 |
| CHEMBL203062 | — | — | 1 | 6.16 |
| CHEMBL204710 | — | — | 1 | 6.00 |
| CHEMBL203974 | — | — | 1 | 5.92 |
| CHEMBL204241 | — | — | 1 | 5.85 |
| CHEMBL383751 | — | — | 1 | 5.82 |
| CHEMBL381405 | — | — | 1 | 5.80 |
| CHEMBL381122 | — | — | 1 | 5.77 |
| CHEMBL383065 | — | — | 1 | 5.77 |
| CHEMBL205124 | — | — | 1 | 5.75 |
| CHEMBL205166 | — | — | 1 | 5.72 |
| CHEMBL379249 | — | — | 1 | 5.70 |
| CHEMBL204180 | — | — | 1 | 5.70 |
| CHEMBL205122 | — | — | 1 | 5.70 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 5.68 |
| CHEMBL203868 | — | — | 1 | 5.66 |
| CHEMBL381961 | — | — | 1 | 5.66 |
| CHEMBL204093 | — | — | 1 | 5.62 |
| CHEMBL381963 | — | — | 1 | 5.47 |
| CHEMBL203704 | — | — | 1 | 5.42 |
| CHEMBL381049 | — | — | 1 | 5.36 |
| CHEMBL382558 | — | — | 1 | 5.31 |
| CHEMBL204811 | — | — | 1 | 5.30 |
| CHEMBL382359 | — | — | 1 | 5.06 |
| CHEMBL382358 | — | — | 1 | 5.02 |
| CHEMBL382619 | — | — | 1 | 4.88 |
| CHEMBL426842 | — | — | 1 | 4.81 |
| CHEMBL383230 | — | — | 1 | 4.74 |
| CHEMBL204754 | — | — | 1 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL203642 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL203755 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL203062 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL204710 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL203974 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL204241 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL383751 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL381405 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL381122 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL383065 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL205124 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL205166 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL379249 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL204180 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL205122 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL203868 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL381961 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL204093 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL381963 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL203704 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL381049 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL382558 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL204811 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL382359 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL382358 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL382619 | — | IC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL426842 | — | IC50 | = | 15500.0 | nM | 4.81 |
| CHEMBL383230 | — | IC50 | = | 18100.0 | nM | 4.74 |
| CHEMBL204754 | — | IC50 | = | 29900.0 | nM | 4.52 |
| CHEMBL204853 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL381330 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL428647 | PACLITAXEL | IC50 | - | — | - | |
| CHEMBL203159 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL204972 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL382867 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL204233 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL383032 | — | IC50 | > | 30000.0 | nM | - |