Assay Detail
Functional
CHEMBL867155
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cell cycle arrest in A431 cells by accumulation at G2/M phase
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-431 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Oxadiazole derivatives as a novel class of antimitotic agents: Synthesis, inhibition of tubulin polymerization, and activity in tumor cell lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 38 | 7.37 | 8.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.46 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.05 |
| CHEMBL203062 | — | — | 1 | 7.89 |
| CHEMBL203974 | — | — | 1 | 7.85 |
| CHEMBL203755 | — | — | 1 | 7.82 |
| CHEMBL205166 | — | — | 1 | 7.80 |
| CHEMBL203642 | — | — | 1 | 7.75 |
| CHEMBL204754 | — | — | 1 | 7.75 |
| CHEMBL204710 | — | — | 1 | 7.70 |
| CHEMBL383751 | — | — | 1 | 7.70 |
| CHEMBL381049 | — | — | 1 | 7.66 |
| CHEMBL381405 | — | — | 1 | 7.64 |
| CHEMBL204180 | — | — | 1 | 7.64 |
| CHEMBL382359 | — | — | 1 | 7.51 |
| CHEMBL381961 | — | — | 1 | 7.51 |
| CHEMBL204241 | — | — | 1 | 7.46 |
| CHEMBL205122 | — | — | 1 | 7.35 |
| CHEMBL381122 | — | — | 1 | 7.31 |
| CHEMBL203868 | — | — | 1 | 7.29 |
| CHEMBL205124 | — | — | 1 | 7.24 |
| CHEMBL204811 | — | — | 1 | 7.22 |
| CHEMBL203704 | — | — | 1 | 7.15 |
| CHEMBL379249 | — | — | 1 | 7.12 |
| CHEMBL381963 | — | — | 1 | 7.09 |
| CHEMBL204093 | — | — | 1 | 7.00 |
| CHEMBL382558 | — | — | 1 | 6.89 |
| CHEMBL383065 | — | — | 1 | 6.80 |
| CHEMBL382358 | — | — | 1 | 6.68 |
| CHEMBL383230 | — | — | 1 | 6.58 |
| CHEMBL426842 | — | — | 1 | 6.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | EC50 | = | 3.5 | nM | 8.46 |
| CHEMBL428647 | PACLITAXEL | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL203062 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL203974 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL203755 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL205166 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL203642 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL204754 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL204710 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL383751 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL381049 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL381405 | — | EC50 | = | 23.0 | nM | 7.64 |
| CHEMBL204180 | — | EC50 | = | 23.0 | nM | 7.64 |
| CHEMBL382359 | — | EC50 | = | 31.0 | nM | 7.51 |
| CHEMBL381961 | — | EC50 | = | 31.0 | nM | 7.51 |
| CHEMBL204241 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL205122 | — | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL381122 | — | EC50 | = | 49.0 | nM | 7.31 |
| CHEMBL203868 | — | EC50 | = | 51.0 | nM | 7.29 |
| CHEMBL205124 | — | EC50 | = | 57.0 | nM | 7.24 |
| CHEMBL204811 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL203704 | — | EC50 | = | 71.0 | nM | 7.15 |
| CHEMBL379249 | — | EC50 | = | 75.0 | nM | 7.12 |
| CHEMBL381963 | — | EC50 | = | 82.0 | nM | 7.09 |
| CHEMBL204093 | — | EC50 | = | 99.0 | nM | 7.00 |
| CHEMBL382558 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL383065 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL382358 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL383230 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL426842 | — | EC50 | = | 330.0 | nM | 6.48 |
| CHEMBL382619 | — | EC50 | = | 780.0 | nM | 6.11 |
| CHEMBL383032 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL204233 | — | EC50 | - | — | - | |
| CHEMBL382867 | — | EC50 | - | — | - | |
| CHEMBL204972 | — | EC50 | - | — | - | |
| CHEMBL203159 | — | EC50 | - | — | - | |
| CHEMBL204853 | — | EC50 | - | — | - | |
| CHEMBL381330 | — | EC50 | - | — | - |