Assay Detail
Binding
CHEMBL867157
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Displacement of [3H]colchicine from tubulin at 65 nM
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Oxadiazole derivatives as a novel class of antimitotic agents: Synthesis, inhibition of tubulin polymerization, and activity in tumor cell lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.19 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL204241 | — | — | 1 | 8.00 |
| CHEMBL381122 | — | — | 1 | 7.52 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 7.52 |
| CHEMBL203062 | — | — | 1 | 7.52 |
| CHEMBL204710 | — | — | 1 | 7.52 |
| CHEMBL381049 | — | — | 1 | 7.12 |
| CHEMBL205166 | — | — | 1 | 6.72 |
| CHEMBL203974 | — | — | 1 | 6.41 |
| CHEMBL383065 | — | — | 1 | 6.41 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL204241 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL381122 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL203062 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL204710 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL381049 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL205166 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL203974 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL383065 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL428647 | PACLITAXEL | IC50 | - | — | - |