Assay Detail
Functional
CHEMBL867179
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonistic potency at rat IP3 type 1 receptor expressed in chicken DT40 cells
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | DT40 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 (CHEMBL2804) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
A systematic study of C-glucoside trisphosphates as myo-inositol trisphosphate receptor ligands. Synthesis of beta-C-glucoside trisphosphates based on the conformational restriction strategy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 7.13 | 8.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL204385 | ADENOPHOSTIN A | — | 1 | 8.68 |
| CHEMBL383049 | — | — | 1 | 8.40 |
| CHEMBL379040 | — | — | 1 | 8.34 |
| CHEMBL382185 | — | — | 1 | 7.95 |
| CHEMBL279107 | INS(1,4,5)P3 | — | 1 | 7.61 |
| CHEMBL205008 | — | — | 1 | 7.31 |
| CHEMBL380941 | — | — | 1 | 6.67 |
| CHEMBL204253 | — | — | 1 | 6.41 |
| CHEMBL383659 | — | — | 1 | 5.97 |
| CHEMBL204903 | — | — | 1 | 5.69 |
| CHEMBL205303 | — | — | 1 | 5.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL204385 | ADENOPHOSTIN A | EC50 | = | 2.1 | nM | 8.68 |
| CHEMBL383049 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL379040 | — | EC50 | = | 4.6 | nM | 8.34 |
| CHEMBL382185 | — | EC50 | = | 11.3 | nM | 7.95 |
| CHEMBL279107 | INS(1,4,5)P3 | EC50 | = | 24.8 | nM | 7.61 |
| CHEMBL205008 | — | EC50 | = | 49.2 | nM | 7.31 |
| CHEMBL380941 | — | EC50 | = | 213.0 | nM | 6.67 |
| CHEMBL204253 | — | EC50 | = | 394.0 | nM | 6.41 |
| CHEMBL383659 | — | EC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL204903 | — | EC50 | = | 2040.0 | nM | 5.69 |
| CHEMBL205303 | — | EC50 | = | 4430.0 | nM | 5.35 |