Assay Detail
Functional
CHEMBL867323
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GSK3 phosphorylation
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
RAC-alpha serine/threonine-protein kinase (CHEMBL4282) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and SAR of oxindole-pyridine-based protein kinase B/Akt inhibitors for treating cancers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.70 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL377603 | — | — | 1 | 6.05 |
| CHEMBL383264 | — | — | 1 | 5.82 |
| CHEMBL212566 | — | — | 1 | 5.71 |
| CHEMBL210954 | — | — | 1 | 5.60 |
| CHEMBL210209 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL377603 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL383264 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL212566 | — | IC50 | = | 1940.0 | nM | 5.71 |
| CHEMBL210954 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL210209 | — | IC50 | = | 5000.0 | nM | 5.30 |