Assay Detail
Binding
CHEMBL867362
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Inhibition of p38alpha
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
p38 MAP kinase inhibitors. Part 3: SAR on 3,4-dihydropyrimido[4,5-d]pyrimidin-2-ones and 3,4-dihydropyrido[4,3-d]pyrimidin-2-ones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 8.74 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL212549 | — | — | 1 | 9.70 |
| CHEMBL319556 | — | — | 1 | 9.70 |
| CHEMBL212803 | — | — | 1 | 9.30 |
| CHEMBL211795 | — | — | 1 | 9.30 |
| CHEMBL377979 | — | — | 1 | 9.22 |
| CHEMBL209442 | — | — | 1 | 9.15 |
| CHEMBL214138 | — | — | 1 | 9.10 |
| CHEMBL96632 | — | — | 1 | 9.00 |
| CHEMBL213142 | — | — | 1 | 9.00 |
| CHEMBL213895 | — | — | 1 | 8.96 |
| CHEMBL212091 | — | — | 1 | 8.92 |
| CHEMBL213986 | — | — | 1 | 8.72 |
| CHEMBL94556 | — | — | 1 | 8.70 |
| CHEMBL211303 | — | — | 1 | 8.70 |
| CHEMBL378717 | — | — | 1 | 8.70 |
| CHEMBL210110 | — | — | 1 | 8.70 |
| CHEMBL213836 | — | — | 1 | 8.70 |
| CHEMBL425785 | — | — | 1 | 8.70 |
| CHEMBL441853 | — | — | 1 | 8.52 |
| CHEMBL213846 | — | — | 1 | 8.40 |
| CHEMBL215651 | — | — | 1 | 8.40 |
| CHEMBL211426 | — | — | 1 | 8.38 |
| CHEMBL212937 | — | — | 1 | 8.38 |
| CHEMBL212821 | — | — | 1 | 8.28 |
| CHEMBL213190 | — | — | 1 | 8.25 |
| CHEMBL425422 | — | — | 1 | 8.22 |
| CHEMBL212753 | — | — | 1 | 8.00 |
| CHEMBL425265 | — | — | 1 | 7.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL212549 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL319556 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL212803 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL211795 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL377979 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL209442 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL214138 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL96632 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL213142 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL213895 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL212091 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL213986 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL94556 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL211303 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL378717 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL210110 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL213836 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL425785 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL441853 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL213846 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL215651 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL211426 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL212937 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL212821 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL213190 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL425422 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL212753 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL425265 | — | IC50 | = | 20.0 | nM | 7.70 |