Assay Detail
Functional
CHEMBL867364
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of LPS-stimulated TNFalpha release in human whole blood
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
p38 MAP kinase inhibitors. Part 3: SAR on 3,4-dihydropyrimido[4,5-d]pyrimidin-2-ones and 3,4-dihydropyrido[4,3-d]pyrimidin-2-ones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.82 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL319556 | — | — | 1 | 8.00 |
| CHEMBL377979 | — | — | 1 | 7.82 |
| CHEMBL212803 | — | — | 1 | 7.77 |
| CHEMBL212549 | — | — | 1 | 7.70 |
| CHEMBL213190 | — | — | 1 | 7.50 |
| CHEMBL209442 | — | — | 1 | 7.42 |
| CHEMBL213142 | — | — | 1 | 7.38 |
| CHEMBL211795 | — | — | 1 | 7.00 |
| CHEMBL211426 | — | — | 1 | 6.60 |
| CHEMBL213836 | — | — | 1 | 6.57 |
| CHEMBL212091 | — | — | 1 | 6.44 |
| CHEMBL213986 | — | — | 1 | 6.30 |
| CHEMBL425785 | — | — | 1 | 6.07 |
| CHEMBL215651 | — | — | 1 | 6.00 |
| CHEMBL214138 | — | — | 1 | 6.00 |
| CHEMBL425265 | — | — | 1 | 5.71 |
| CHEMBL212821 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL319556 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL377979 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL212803 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL212549 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL213190 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL209442 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL213142 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL211795 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL211426 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL213836 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL212091 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL213986 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL425785 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL215651 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL214138 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL425265 | — | IC50 | = | 1940.0 | nM | 5.71 |
| CHEMBL212821 | — | IC50 | = | 2000.0 | nM | 5.70 |