Assay Detail
Functional
CHEMBL867374
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 Y181S mutant
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Design, synthesis, and biological evaluations of novel quinolones as HIV-1 non-nucleoside reverse transcriptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 6.10 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 9.00 |
| CHEMBL210506 | — | — | 1 | 6.43 |
| CHEMBL212058 | — | — | 1 | 6.24 |
| CHEMBL377229 | — | — | 1 | 6.17 |
| CHEMBL377039 | — | — | 1 | 6.04 |
| CHEMBL209487 | — | — | 1 | 6.03 |
| CHEMBL213512 | — | — | 1 | 6.03 |
| CHEMBL211437 | — | — | 1 | 5.92 |
| CHEMBL208792 | — | — | 1 | 5.77 |
| CHEMBL210171 | — | — | 1 | 5.63 |
| CHEMBL211780 | — | — | 1 | 5.60 |
| CHEMBL209524 | — | — | 1 | 5.57 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 5.52 |
| CHEMBL378177 | — | — | 1 | 5.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL210506 | — | EC50 | = | 369.0 | nM | 6.43 |
| CHEMBL212058 | — | EC50 | = | 581.0 | nM | 6.24 |
| CHEMBL377229 | — | EC50 | = | 684.0 | nM | 6.17 |
| CHEMBL377039 | — | EC50 | = | 901.0 | nM | 6.04 |
| CHEMBL209487 | — | EC50 | = | 929.0 | nM | 6.03 |
| CHEMBL213512 | — | EC50 | = | 932.0 | nM | 6.03 |
| CHEMBL211437 | — | EC50 | = | 1213.0 | nM | 5.92 |
| CHEMBL208792 | — | EC50 | = | 1681.0 | nM | 5.77 |
| CHEMBL210171 | — | EC50 | = | 2354.0 | nM | 5.63 |
| CHEMBL211780 | — | EC50 | = | 2525.0 | nM | 5.60 |
| CHEMBL209524 | — | EC50 | = | 2704.0 | nM | 5.57 |
| CHEMBL57 | NEVIRAPINE | EC50 | = | 3001.0 | nM | 5.52 |
| CHEMBL378177 | — | EC50 | = | 4180.0 | nM | 5.38 |