Assay Detail
Binding
CHEMBL867413
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Displacement of [3H]clonidine from Sprague-Dawley rat cortex adrenergic alpha 2 receptor
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Comparison of the binding of 3-fluoromethyl-7-sulfonyl-1,2,3,4-tetrahydroisoquinolines with their isosteric sulfonamides to the active site of phenylethanolamine N-methyltransferase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 5.08 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL287837 | — | — | 1 | 7.68 |
| CHEMBL14346 | 1,2,3,4-TETRAHYDROISOQUINOLINE | — | 1 | 6.46 |
| CHEMBL28431 | — | — | 1 | 4.68 |
| CHEMBL27599 | — | — | 1 | 4.47 |
| CHEMBL176112 | — | — | 1 | 4.28 |
| CHEMBL280592 | — | — | 1 | 4.02 |
| CHEMBL26717 | — | — | 1 | 4.00 |
| CHEMBL41647 | — | — | 1 | - |
| CHEMBL290890 | — | — | 1 | - |
| CHEMBL184931 | — | — | 1 | - |
| CHEMBL435536 | — | — | 1 | - |
| CHEMBL177861 | — | — | 1 | - |
| CHEMBL120975 | — | — | 1 | - |
| CHEMBL177621 | — | — | 1 | - |
| CHEMBL366785 | — | — | 1 | - |
| CHEMBL178695 | — | — | 1 | - |
| CHEMBL95873 | — | — | 1 | - |
| CHEMBL213339 | — | — | 1 | - |
| CHEMBL214064 | — | — | 1 | - |
| CHEMBL213579 | — | — | 1 | - |
| CHEMBL212790 | — | — | 1 | - |
| CHEMBL215871 | — | — | 1 | - |
| CHEMBL212026 | — | — | 1 | - |
| CHEMBL213031 | — | — | 1 | - |
| CHEMBL333578 | — | — | 1 | - |
| CHEMBL27664 | — | — | 1 | - |
| CHEMBL439320 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL287837 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL14346 | 1,2,3,4-TETRAHYDROISOQUINOLINE | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL28431 | — | Ki | = | 21000.0 | nM | 4.68 |
| CHEMBL27599 | — | Ki | = | 34000.0 | nM | 4.47 |
| CHEMBL176112 | — | Ki | = | 53000.0 | nM | 4.28 |
| CHEMBL280592 | — | Ki | = | 95000.0 | nM | 4.02 |
| CHEMBL26717 | — | Ki | = | 100000.0 | nM | 4.00 |
| CHEMBL41647 | — | Ki | = | 1400000.0 | nM | - |
| CHEMBL290890 | — | Ki | = | 140000.0 | nM | - |
| CHEMBL184931 | — | Ki | = | 430000.0 | nM | - |
| CHEMBL435536 | — | Ki | = | 610000.0 | nM | - |
| CHEMBL177861 | — | Ki | = | 550000.0 | nM | - |
| CHEMBL120975 | — | Ki | = | 310000.0 | nM | - |
| CHEMBL177621 | — | Ki | = | 660000.0 | nM | - |
| CHEMBL366785 | — | Ki | = | 340000.0 | nM | - |
| CHEMBL178695 | — | Ki | = | 1200000.0 | nM | - |
| CHEMBL95873 | — | Ki | = | 680000.0 | nM | - |
| CHEMBL213339 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL214064 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL213579 | — | Ki | = | 1100000.0 | nM | - |
| CHEMBL212790 | — | Ki | = | 690000.0 | nM | - |
| CHEMBL215871 | — | Ki | = | 540000.0 | nM | - |
| CHEMBL212026 | — | Ki | = | 1200000.0 | nM | - |
| CHEMBL213031 | — | Ki | = | 740000.0 | nM | - |
| CHEMBL333578 | — | Ki | = | 230000.0 | nM | - |
| CHEMBL27664 | — | Ki | = | 160000.0 | nM | - |
| CHEMBL439320 | — | Ki | > | 1000000.0 | nM | - |