Assay Detail
Binding
CHEMBL867594
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]DAMGO from mu opioid receptor expressed in rat brain synaptosomal membranes
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Potent Dmt-Tic pharmacophoric delta- and mu-opioid receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 8.37 | 8.86 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL196774 | — | — | 1 | 8.86 |
| CHEMBL198646 | — | — | 1 | 8.81 |
| CHEMBL261905 | — | — | 1 | 8.78 |
| CHEMBL373668 | — | — | 1 | 8.76 |
| CHEMBL197185 | — | — | 1 | 8.75 |
| CHEMBL370399 | — | — | 1 | 8.66 |
| CHEMBL370398 | — | — | 1 | 8.64 |
| CHEMBL198800 | — | — | 1 | 8.55 |
| CHEMBL381874 | — | — | 1 | 8.51 |
| CHEMBL200890 | — | — | 1 | 8.43 |
| CHEMBL373192 | — | — | 1 | 8.31 |
| CHEMBL370197 | — | — | 1 | 8.24 |
| CHEMBL571492 | — | — | 1 | 5.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL196774 | — | Ki | = | 1.37 | nM | 8.86 |
| CHEMBL198646 | — | Ki | = | 1.56 | nM | 8.81 |
| CHEMBL261905 | — | Ki | = | 1.68 | nM | 8.78 |
| CHEMBL373668 | — | Ki | = | 1.74 | nM | 8.76 |
| CHEMBL197185 | — | Ki | = | 1.79 | nM | 8.75 |
| CHEMBL370399 | — | Ki | = | 2.21 | nM | 8.66 |
| CHEMBL370398 | — | Ki | = | 2.28 | nM | 8.64 |
| CHEMBL198800 | — | Ki | = | 2.83 | nM | 8.55 |
| CHEMBL381874 | — | Ki | = | 3.08 | nM | 8.51 |
| CHEMBL200890 | — | Ki | = | 3.76 | nM | 8.43 |
| CHEMBL373192 | — | Ki | = | 4.86 | nM | 8.31 |
| CHEMBL370197 | — | Ki | = | 5.72 | nM | 8.24 |
| CHEMBL571492 | — | Ki | = | 3320.0 | nM | 5.48 |