Assay Detail
Binding
CHEMBL867597
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Displacement of deltorphin-II from delta opioid receptor in mouse vas deferens
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Potent Dmt-Tic pharmacophoric delta- and mu-opioid receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 14 | 10.32 | 10.99 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL196774 | — | — | 1 | 10.99 |
| CHEMBL373192 | — | — | 1 | 10.97 |
| CHEMBL198800 | — | — | 1 | 10.73 |
| CHEMBL197185 | — | — | 1 | 10.62 |
| CHEMBL198646 | — | — | 1 | 10.60 |
| CHEMBL381874 | — | — | 1 | 10.56 |
| CHEMBL370197 | — | — | 1 | 10.51 |
| CHEMBL370398 | — | — | 1 | 10.47 |
| CHEMBL261905 | — | — | 1 | 10.42 |
| CHEMBL567175 | NALTRINDOLE | — | 1 | 9.20 |
| CHEMBL571492 | — | — | 1 | 8.48 |
| CHEMBL200890 | — | — | 1 | - |
| CHEMBL373668 | — | — | 1 | - |
| CHEMBL370399 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL196774 | — | Kd | = | 0.01023 | nM | 10.99 |
| CHEMBL373192 | — | Kd | = | 0.01072 | nM | 10.97 |
| CHEMBL198800 | — | Kd | = | 0.01862 | nM | 10.73 |
| CHEMBL197185 | — | Kd | = | 0.02399 | nM | 10.62 |
| CHEMBL198646 | — | Kd | = | 0.02512 | nM | 10.60 |
| CHEMBL381874 | — | Kd | = | 0.02754 | nM | 10.56 |
| CHEMBL370197 | — | Kd | = | 0.0309 | nM | 10.51 |
| CHEMBL370398 | — | Kd | = | 0.03388 | nM | 10.47 |
| CHEMBL261905 | — | Kd | = | 0.03802 | nM | 10.42 |
| CHEMBL567175 | NALTRINDOLE | Kd | = | 0.631 | nM | 9.20 |
| CHEMBL571492 | — | Kd | = | 3.311 | nM | 8.48 |
| CHEMBL200890 | — | Kd | = | 0.006026 | nM | - |
| CHEMBL373668 | — | Kd | = | 0.00871 | nM | - |
| CHEMBL370399 | — | Kd | = | 0.005248 | nM | - |