Assay Detail
Functional
CHEMBL867599
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonistic activity at mu opioid receptor in myenteric plexus longitudinal muscle of guinea pig ileum
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Potent Dmt-Tic pharmacophoric delta- and mu-opioid receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.33 | 5.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL197185 | — | — | 1 | 5.57 |
| CHEMBL373192 | — | — | 1 | 5.27 |
| CHEMBL381874 | — | — | 1 | 5.15 |
| CHEMBL200890 | — | — | 1 | - |
| CHEMBL198800 | — | — | 1 | - |
| CHEMBL373668 | — | — | 1 | - |
| CHEMBL198646 | — | — | 1 | - |
| CHEMBL370398 | — | — | 1 | - |
| CHEMBL196774 | — | — | 1 | - |
| CHEMBL370197 | — | — | 1 | - |
| CHEMBL370399 | — | — | 1 | - |
| CHEMBL261905 | — | — | 1 | - |
| CHEMBL571492 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL197185 | — | IC50 | = | 2715.0 | nM | 5.57 |
| CHEMBL373192 | — | IC50 | = | 5425.0 | nM | 5.27 |
| CHEMBL381874 | — | IC50 | = | 7025.0 | nM | 5.15 |
| CHEMBL200890 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL198800 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL373668 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL198646 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL370398 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL196774 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL370197 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL370399 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL261905 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL571492 | — | IC50 | - | — | - |