Assay Detail
Binding
CHEMBL867736
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Inhibition of MMP1
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Acetylenic TACE inhibitors. Part 3: Thiomorpholine sulfonamide hydroxamates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 7.52 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL207776 | — | — | 1 | 9.00 |
| CHEMBL206688 | — | — | 1 | 8.70 |
| CHEMBL440945 | — | — | 1 | 8.22 |
| CHEMBL207729 | — | — | 1 | 8.15 |
| CHEMBL383079 | — | — | 1 | 8.15 |
| CHEMBL380439 | — | — | 1 | 8.15 |
| CHEMBL441177 | — | — | 1 | 7.96 |
| CHEMBL381163 | — | — | 1 | 7.77 |
| CHEMBL206481 | — | — | 1 | 7.72 |
| CHEMBL381554 | — | — | 1 | 7.68 |
| CHEMBL204100 | — | — | 1 | 7.68 |
| CHEMBL437499 | — | — | 1 | 7.58 |
| CHEMBL206298 | — | — | 1 | 7.54 |
| CHEMBL205998 | — | — | 1 | 7.48 |
| CHEMBL206815 | APRATASTAT | 2.0 | 1 | 7.48 |
| CHEMBL202806 | — | — | 1 | 7.46 |
| CHEMBL206739 | — | — | 1 | 7.46 |
| CHEMBL206155 | — | — | 1 | 7.38 |
| CHEMBL381505 | — | — | 1 | 7.06 |
| CHEMBL203886 | — | — | 1 | 7.04 |
| CHEMBL202839 | — | — | 1 | 7.01 |
| CHEMBL382585 | — | — | 1 | 7.00 |
| CHEMBL206144 | — | — | 1 | 6.80 |
| CHEMBL383028 | — | — | 1 | 6.65 |
| CHEMBL380343 | — | — | 1 | 6.52 |
| CHEMBL202899 | — | — | 1 | 5.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL207776 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL206688 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL440945 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL207729 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL383079 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL380439 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL441177 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL381163 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL206481 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL381554 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL204100 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL437499 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL206298 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL205998 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL206815 | APRATASTAT | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL202806 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL206739 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL206155 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL381505 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL203886 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL202839 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL382585 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL206144 | — | IC50 | = | 159.0 | nM | 6.80 |
| CHEMBL383028 | — | IC50 | = | 226.0 | nM | 6.65 |
| CHEMBL380343 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL202899 | — | IC50 | = | 1052.0 | nM | 5.98 |