Assay Detail
Binding
CHEMBL867889
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Inhibition of mammalian CDK5/p25
66
Total Activities
65
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 5/CDK5 activator 1 (CHEMBL1907600) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
3'-Substituted 7-halogenoindirubins, a new class of cell death inducing agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 66 | 5.81 | 7.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL253770 | INDIRUBIN 2 | — | 1 | 7.55 |
| CHEMBL409450 | 6BIO | — | 1 | 7.08 |
| CHEMBL126077 | INDIRUBIN-3-MONOXIME | — | 1 | 7.00 |
| CHEMBL211243 | — | — | 1 | 6.40 |
| CHEMBL212174 | — | — | 1 | 6.29 |
| CHEMBL209849 | — | — | 1 | 6.16 |
| CHEMBL213650 | — | — | 1 | 5.22 |
| CHEMBL1276127 | INDIRUBIN | 2.0 | 1 | 5.00 |
| CHEMBL377410 | — | — | 1 | 4.60 |
| CHEMBL373834 | — | — | 1 | 4.48 |
| CHEMBL209648 | — | — | 1 | 4.11 |
| CHEMBL378787 | — | — | 1 | - |
| CHEMBL211445 | — | — | 1 | - |
| CHEMBL212057 | — | — | 1 | - |
| CHEMBL379378 | — | — | 1 | - |
| CHEMBL378191 | — | — | 1 | - |
| CHEMBL211205 | — | — | 1 | - |
| CHEMBL380053 | — | — | 1 | - |
| CHEMBL380241 | — | — | 1 | - |
| CHEMBL213128 | — | — | 1 | - |
| CHEMBL213506 | — | — | 1 | - |
| CHEMBL213454 | — | — | 1 | - |
| CHEMBL375870 | — | — | 1 | - |
| CHEMBL213742 | — | — | 1 | - |
| CHEMBL436748 | — | — | 1 | - |
| CHEMBL214173 | — | — | 1 | - |
| CHEMBL378849 | — | — | 1 | - |
| CHEMBL212465 | — | — | 1 | - |
| CHEMBL209968 | — | — | 1 | - |
| CHEMBL378205 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL253770 | INDIRUBIN 2 | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL409450 | 6BIO | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL126077 | INDIRUBIN-3-MONOXIME | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL211243 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL212174 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL209849 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL213650 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL1276127 | INDIRUBIN | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL377410 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL373834 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL209648 | — | IC50 | = | 77000.0 | nM | 4.11 |
| CHEMBL212057 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL211093 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL211445 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL378787 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL210073 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL379146 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL211192 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL377536 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL378485 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL211457 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL378059 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL211192 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL379878 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL213077 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL208540 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL378198 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL212581 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL379713 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL379858 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL366438 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL212465 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL213128 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL209968 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL213506 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL213454 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL375870 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL213742 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL436748 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL435707 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL379378 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL214173 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL378849 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL211593 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL378205 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL380241 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL380053 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL211205 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL210446 | — | IC50 | >= | 10000.0 | nM | - |
| CHEMBL378191 | — | IC50 | > | 100000.0 | nM | - |