Assay Detail
Functional
CHEMBL867905
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Death of human SH-SY5Y cells in absence of 20 uM Q-VD-OPh by MTS reduction assay
16
Total Activities
16
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SH-SY5Y |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
3'-Substituted 7-halogenoindirubins, a new class of cell death inducing agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.24 | 5.96 |
| IC100 | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL378198 | — | — | 1 | 5.96 |
| CHEMBL212581 | — | — | 1 | 5.82 |
| CHEMBL211429 | — | — | 1 | 5.70 |
| CHEMBL211430 | — | — | 1 | 5.55 |
| CHEMBL377981 | — | — | 1 | 5.30 |
| CHEMBL379713 | — | — | 1 | 5.21 |
| CHEMBL210104 | — | — | 1 | 5.21 |
| CHEMBL208540 | — | — | 1 | 5.19 |
| CHEMBL373834 | — | — | 1 | 5.16 |
| CHEMBL409450 | 6BIO | — | 1 | 5.00 |
| CHEMBL213650 | — | — | 1 | 5.00 |
| CHEMBL213077 | — | — | 1 | 4.96 |
| CHEMBL126077 | INDIRUBIN-3-MONOXIME | — | 1 | 4.89 |
| CHEMBL253770 | INDIRUBIN 2 | — | 1 | 4.89 |
| CHEMBL211457 | — | — | 1 | 4.75 |
| CHEMBL379858 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL378198 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL212581 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL211429 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL211430 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL377981 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL379713 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL210104 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL208540 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL373834 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL409450 | 6BIO | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL213650 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL213077 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL126077 | INDIRUBIN-3-MONOXIME | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL253770 | INDIRUBIN 2 | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL211457 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL379858 | — | IC100 | = | 10.0 | uM | - |