Assay Detail
Binding
CHEMBL868042
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Inhibition of AKT3 in presence of 0.2 uM ATP
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
RAC-gamma serine/threonine-protein kinase (CHEMBL4816) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of 2-pyrimidyl-5-amidothiophenes as potent inhibitors for AKT: synthesis and SAR studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 5.99 | 8.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL213618 | — | — | 1 | 8.59 |
| CHEMBL379507 | — | — | 1 | 8.32 |
| CHEMBL384964 | — | — | 1 | 7.96 |
| CHEMBL385143 | — | — | 1 | 7.57 |
| CHEMBL380165 | — | — | 1 | 6.62 |
| CHEMBL211578 | — | — | 1 | 6.55 |
| CHEMBL377568 | — | — | 1 | 6.21 |
| CHEMBL212450 | — | — | 1 | 6.18 |
| CHEMBL379263 | — | — | 1 | 6.09 |
| CHEMBL209838 | — | — | 1 | 6.00 |
| CHEMBL211570 | — | — | 1 | 6.00 |
| CHEMBL376004 | — | — | 1 | 5.96 |
| CHEMBL209475 | — | — | 1 | 5.89 |
| CHEMBL211574 | — | — | 1 | 5.82 |
| CHEMBL376424 | — | — | 1 | 5.68 |
| CHEMBL213181 | — | — | 1 | 5.64 |
| CHEMBL210115 | — | — | 1 | 5.62 |
| CHEMBL213127 | — | — | 1 | 5.58 |
| CHEMBL209952 | — | — | 1 | 5.55 |
| CHEMBL210071 | — | — | 1 | 5.54 |
| CHEMBL380402 | — | — | 1 | 5.52 |
| CHEMBL425964 | — | — | 1 | 5.33 |
| CHEMBL209547 | — | — | 1 | 5.30 |
| CHEMBL214906 | — | — | 1 | 5.28 |
| CHEMBL378721 | — | — | 1 | 5.27 |
| CHEMBL377860 | — | — | 1 | 5.16 |
| CHEMBL214339 | — | — | 1 | 5.13 |
| CHEMBL213178 | — | — | 1 | 4.75 |
| CHEMBL213633 | — | — | 1 | 4.72 |
| CHEMBL379133 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL213618 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL379507 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL384964 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL385143 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL380165 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL211578 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL377568 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL212450 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL379263 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL211570 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL209838 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL376004 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL209475 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL211574 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL376424 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL213181 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL210115 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL213127 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL209952 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL210071 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL380402 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL425964 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL209547 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL214906 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL378721 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL377860 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL214339 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL213178 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL213633 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL379133 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL379644 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL212814 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL214070 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL213139 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL213707 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL214193 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL213756 | — | IC50 | > | 25000.0 | nM | - |