Compound Detail
CHEMBL213181
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Basic Information
| ChEMBL ID | CHEMBL213181 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ORMFNQBOCNXRRU-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
356.4
MW (Da)
3.96
ALogP
5
HBA
2
HBD
66.9
PSA (Ų)
0.70
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.64
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| RAC-gamma serine/threonine-protein kinase CHEMBL4816 | IC50 | 5.64 | 5.64 | 2300.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| RAC-gamma serine/threonine-protein kinase | IC50 | = | 2300.0 | nM | 5.64 | Inhibition of AKT3 in presence of 0.2 uM ATP | 16765046 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16765046 | 10.1016/j.bmcl.2006.05.092 | RAC-gamma serine/threonine-protein kinase | 1 |
Data from ChEMBL 36 via Core Engine