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Assay Detail

CHEMBL868072

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against HIV1 NL4-3 in MT4 cells
14
Total Activities
14
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Cell Type MT4
Confidence 1 — Organism
Curated By Expert

Target

MT4 (CHEMBL388)
Type CELL-LINE
Organism Homo sapiens

Publication

Anti-AIDS agents 69. Moronic acid and other triterpene derivatives as novel potent anti-HIV agents.
Yu D, Sakurai Y, Chen CH, Chang FR, Huang L, Kashiwada Y, Lee KH.
J Med Chem (2006) 49 : 5462 -5469
PubMed 16942019 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 9 6.71 8.15
Activity 5 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL437716 1 8.15
CHEMBL214175 1 8.07
CHEMBL385858 1 8.00
CHEMBL215571 1 7.35
CHEMBL404519 BEVIRIMAT 2.0 1 7.02
CHEMBL215572 1 6.96
CHEMBL211369 1 5.08
CHEMBL211684 1 5.08
CHEMBL211376 1 4.67
CHEMBL318169 1 -
CHEMBL266607 1 -
CHEMBL377754 1 -
CHEMBL215393 1 -
CHEMBL380308 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL437716 EC50 = 7.0 nM 8.15
CHEMBL214175 EC50 = 8.5 nM 8.07
CHEMBL385858 EC50 = 10.0 nM 8.00
CHEMBL215571 EC50 = 45.0 nM 7.35
CHEMBL404519 BEVIRIMAT EC50 = 96.0 nM 7.02
CHEMBL215572 EC50 = 110.0 nM 6.96
CHEMBL211369 EC50 = 8300.0 nM 5.08
CHEMBL211684 EC50 = 8300.0 nM 5.08
CHEMBL211376 EC50 = 21600.0 nM 4.67
CHEMBL318169 Activity - -
CHEMBL266607 Activity - -
CHEMBL377754 Activity - -
CHEMBL215393 Activity - -
CHEMBL380308 Activity - -