Assay Detail
Binding
CHEMBL868099
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Inhibition of ovine COX2
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Ovis aries |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Selective COX-2 inhibitors. Part 1: synthesis and biological evaluation of phenylazobenzenesulfonamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.16 | 6.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 6.47 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 6.36 |
| CHEMBL165 | RESVERATROL | 3.0 | 1 | 5.46 |
| CHEMBL17161 | — | — | 1 | 4.75 |
| CHEMBL377353 | SALAZOSULFAMIDE | 2.0 | 1 | 4.63 |
| CHEMBL215872 | — | — | 1 | 4.40 |
| CHEMBL213326 | — | — | 1 | 4.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL118 | CELECOXIB | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL165 | RESVERATROL | IC50 | = | 3490.0 | nM | 5.46 |
| CHEMBL17161 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL377353 | SALAZOSULFAMIDE | IC50 | = | 23600.0 | nM | 4.63 |
| CHEMBL215872 | — | IC50 | = | 39700.0 | nM | 4.40 |
| CHEMBL213326 | — | IC50 | = | 84500.0 | nM | 4.07 |