Compound Detail
CHEMBL377353
SALAZOSULFAMIDE 🧪 Phase II
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL377353 |
| Name | SALAZOSULFAMIDE |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | NBSRUZQXRUNPNY-FOCLMDBBSA-N |
5
Targets
5
Activities
1
Assay Types
0
PK Parameters
6
Publications
3
Known Names
Molecular Properties
321.3
MW (Da)
2.15
ALogP
6
HBA
3
HBD
142.4
PSA (Ų)
0.74
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Activity Summary
IC50 5 meas. best 5.05
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Prostaglandin G/H synthase 2 CHEMBL230 | IC50 | 5.05 | 5.05 | 8890.0 | 1 |
| Prostaglandin G/H synthase 2 CHEMBL4102 | IC50 | 4.63 | 4.63 | 23600.0 | 1 |
| Prostaglandin G/H synthase 1 CHEMBL2949 | IC50 | 4.53 | 4.53 | 29250.0 | 1 |
| Prostaglandin G/H synthase 1 CHEMBL221 | IC50 | 4.5 | 4.5 | 31570.0 | 1 |
| PH domain leucine-rich repeat-containing protein phosphatase 2 CHEMBL1275209 | IC50 | 4.12 | 4.12 | 75000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Prostaglandin G/H synthase 2 | IC50 | = | 8890.0 | nM | 5.05 | Inhibition of COX2 assessed as LPS-stimulated PGE2 production in human whole blo... | 16814546 |
| Prostaglandin G/H synthase 2 | IC50 | = | 23600.0 | nM | 4.63 | Inhibition of ovine COX2 | 16814546 |
| Prostaglandin G/H synthase 1 | IC50 | = | 29250.0 | nM | 4.53 | Inhibition of ovine COX1 | 16814546 |
| Prostaglandin G/H synthase 1 | IC50 | = | 31570.0 | nM | 4.5 | Inhibition of COX1 assessed as TBX2 production in human whole blood | 16814546 |
| PH domain leucine-rich repeat-containing protein phosphatase 2 | IC50 | = | 75000.0 | nM | 4.12 | Inhibition of PHLPP2 phosphatase domain expressed in Escherichia coli | 20836557 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16814546 | 10.1016/j.bmcl.2006.06.036 | Prostaglandin G/H synthase 2 | 2 |
| 16814546 | 10.1016/j.bmcl.2006.06.036 | Prostaglandin G/H synthase 1 | 2 |
| 16814546 | 10.1016/j.bmcl.2006.06.036 | Prostaglandin G/H synthase (cyclooxygenase) | 1 |
| 16814546 | 10.1016/j.bmcl.2006.06.036 | Cyclooxygenase | 1 |
| 20836557 | 10.1021/jm100331d | PH domain leucine-rich repeat-containing protein phosphatase 2 | 1 |
| 20836557 | 10.1021/jm100331d | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine