Assay Detail
Functional
CHEMBL869264
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Inhibition of COX2 assessed as LPS-stimulated PGE2 production in human whole blood leukocyte
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Selective COX-2 inhibitors. Part 1: synthesis and biological evaluation of phenylazobenzenesulfonamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.32 | 7.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 7.44 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 6.48 |
| CHEMBL17161 | — | — | 1 | 5.69 |
| CHEMBL213326 | — | — | 1 | 5.37 |
| CHEMBL377353 | SALAZOSULFAMIDE | 2.0 | 1 | 5.05 |
| CHEMBL212918 | — | — | 1 | 4.96 |
| CHEMBL215872 | — | — | 1 | 4.95 |
| CHEMBL386992 | — | — | 1 | 4.91 |
| CHEMBL213939 | — | — | 1 | 4.91 |
| CHEMBL213267 | — | — | 1 | 4.83 |
| CHEMBL214710 | — | — | 1 | 4.77 |
| CHEMBL165 | RESVERATROL | 3.0 | 1 | 4.48 |
| CHEMBL379206 | — | — | 1 | - |
| CHEMBL213266 | — | — | 1 | - |
| CHEMBL277836 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL118 | CELECOXIB | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL17161 | — | IC50 | = | 2040.0 | nM | 5.69 |
| CHEMBL213326 | — | IC50 | = | 4280.0 | nM | 5.37 |
| CHEMBL377353 | SALAZOSULFAMIDE | IC50 | = | 8890.0 | nM | 5.05 |
| CHEMBL212918 | — | IC50 | = | 11070.0 | nM | 4.96 |
| CHEMBL215872 | — | IC50 | = | 11340.0 | nM | 4.95 |
| CHEMBL386992 | — | IC50 | = | 12420.0 | nM | 4.91 |
| CHEMBL213939 | — | IC50 | = | 12370.0 | nM | 4.91 |
| CHEMBL213267 | — | IC50 | = | 14630.0 | nM | 4.83 |
| CHEMBL214710 | — | IC50 | = | 16850.0 | nM | 4.77 |
| CHEMBL165 | RESVERATROL | IC50 | = | 33150.0 | nM | 4.48 |
| CHEMBL379206 | — | IC50 | - | — | - | |
| CHEMBL213266 | — | IC50 | - | — | - | |
| CHEMBL277836 | — | IC50 | - | — | - |