Assay Detail
Functional
CHEMBL866165
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Inhibition of COX1 assessed as TBX2 production in human whole blood
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Selective COX-2 inhibitors. Part 1: synthesis and biological evaluation of phenylazobenzenesulfonamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 4.89 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 8.30 |
| CHEMBL165 | RESVERATROL | 3.0 | 1 | 5.55 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 4.70 |
| CHEMBL17161 | — | — | 1 | 4.63 |
| CHEMBL213939 | — | — | 1 | 4.58 |
| CHEMBL377353 | SALAZOSULFAMIDE | 2.0 | 1 | 4.50 |
| CHEMBL215872 | — | — | 1 | 4.48 |
| CHEMBL212918 | — | — | 1 | 4.46 |
| CHEMBL386992 | — | — | 1 | 4.22 |
| CHEMBL213326 | — | — | 1 | 4.21 |
| CHEMBL213266 | — | — | 1 | 4.18 |
| CHEMBL214710 | — | — | 1 | - |
| CHEMBL379206 | — | — | 1 | - |
| CHEMBL213267 | — | — | 1 | - |
| CHEMBL277836 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL165 | RESVERATROL | IC50 | = | 2840.0 | nM | 5.55 |
| CHEMBL118 | CELECOXIB | IC50 | = | 20030.0 | nM | 4.70 |
| CHEMBL17161 | — | IC50 | = | 23280.0 | nM | 4.63 |
| CHEMBL213939 | — | IC50 | = | 26260.0 | nM | 4.58 |
| CHEMBL377353 | SALAZOSULFAMIDE | IC50 | = | 31570.0 | nM | 4.50 |
| CHEMBL215872 | — | IC50 | = | 33320.0 | nM | 4.48 |
| CHEMBL212918 | — | IC50 | = | 35070.0 | nM | 4.46 |
| CHEMBL386992 | — | IC50 | = | 59960.0 | nM | 4.22 |
| CHEMBL213326 | — | IC50 | = | 61730.0 | nM | 4.21 |
| CHEMBL213266 | — | IC50 | = | 66410.0 | nM | 4.18 |
| CHEMBL214710 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL379206 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL213267 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL277836 | — | IC50 | > | 100000.0 | nM | - |