Assay Detail
Binding
CHEMBL868101
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]strychnine from strychnine-sensitive glycine receptor in rat spinal cord
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.40 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL227934 | STRYCHNINE | -1.0 | 1 | 7.85 |
| CHEMBL213907 | THIOCOLCHICOSIDE | 3.0 | 1 | 5.82 |
| CHEMBL213312 | — | — | 1 | 5.48 |
| CHEMBL215655 | — | — | 1 | 5.39 |
| CHEMBL214151 | — | — | 1 | 5.38 |
| CHEMBL213034 | — | — | 1 | 5.34 |
| CHEMBL386430 | — | — | 1 | 5.07 |
| CHEMBL438794 | — | — | 1 | 4.97 |
| CHEMBL214305 | — | — | 1 | 4.88 |
| CHEMBL773 | GLYCINE | 4.0 | 1 | 4.80 |
| CHEMBL213015 | — | — | 1 | 4.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL227934 | STRYCHNINE | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL213907 | THIOCOLCHICOSIDE | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL213312 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL215655 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL214151 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL213034 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL386430 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL438794 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL214305 | — | IC50 | = | 13100.0 | nM | 4.88 |
| CHEMBL773 | GLYCINE | IC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL213015 | — | IC50 | = | 39900.0 | nM | 4.40 |