Assay Detail
Binding
CHEMBL868105
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cells
11
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Pharmacophore based receptor modeling: the case of adenosine A3 receptor antagonists. An approach to the optimization of protein models.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.46 | 6.46 |
| Inhibition | 5 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL211341 | — | — | 1 | 6.46 |
| CHEMBL211841 | — | — | 2 | - |
| CHEMBL212268 | — | — | 2 | - |
| CHEMBL209479 | — | — | 2 | - |
| CHEMBL208686 | — | — | 2 | - |
| CHEMBL377248 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL211341 | — | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL211841 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL212268 | — | Inhibition | = | 92.0 | % | - |
| CHEMBL212268 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL211841 | — | Inhibition | = | 74.0 | % | - |
| CHEMBL209479 | — | Inhibition | = | 85.0 | % | - |
| CHEMBL209479 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL208686 | — | Inhibition | = | 74.0 | % | - |
| CHEMBL208686 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL377248 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL377248 | — | Inhibition | = | 71.0 | % | - |