Assay Detail
Binding
CHEMBL868168
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Displacement of p53 mimicking fluorescent peptide from Hdm2 by FP assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Enantiomerically pure 1,4-benzodiazepine-2,5-diones as Hdm2 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.85 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL377614 | — | — | 1 | 6.60 |
| CHEMBL377203 | — | — | 1 | 6.43 |
| CHEMBL210545 | — | — | 1 | 6.41 |
| CHEMBL208562 | — | — | 1 | 6.26 |
| CHEMBL207364 | — | — | 1 | 6.10 |
| CHEMBL210151 | — | — | 1 | 6.07 |
| CHEMBL378662 | — | — | 1 | 5.81 |
| CHEMBL207202 | — | — | 1 | 5.62 |
| CHEMBL209201 | — | — | 1 | 5.57 |
| CHEMBL207541 | — | — | 1 | 5.27 |
| CHEMBL378851 | — | — | 1 | 5.20 |
| CHEMBL377639 | — | — | 1 | 4.88 |
| CHEMBL207013 | — | — | 1 | - |
| CHEMBL425780 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL377614 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL377203 | — | IC50 | = | 367.0 | nM | 6.43 |
| CHEMBL210545 | — | IC50 | = | 394.0 | nM | 6.41 |
| CHEMBL208562 | — | IC50 | = | 546.0 | nM | 6.26 |
| CHEMBL207364 | — | IC50 | = | 787.0 | nM | 6.10 |
| CHEMBL210151 | — | IC50 | = | 856.0 | nM | 6.07 |
| CHEMBL378662 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL207202 | — | IC50 | = | 2390.0 | nM | 5.62 |
| CHEMBL209201 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL207541 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL378851 | — | IC50 | = | 6250.0 | nM | 5.20 |
| CHEMBL377639 | — | IC50 | = | 13100.0 | nM | 4.88 |
| CHEMBL207013 | — | IC50 | > | 12500.0 | nM | - |
| CHEMBL425780 | — | IC50 | - | — | - |