Assay Detail
Functional
CHEMBL868224
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Antiproliferative activity against human CCRF-CEM cell line
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Potent antitumor 9-anilinoacridines and acridines bearing an alkylating N-mustard residue on the acridine chromophore: synthesis and biological activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 8.05 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 9.40 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.96 |
| CHEMBL210696 | — | — | 1 | 8.43 |
| CHEMBL210758 | — | — | 1 | 8.39 |
| CHEMBL378694 | — | — | 1 | 8.38 |
| CHEMBL209414 | — | — | 1 | 8.38 |
| CHEMBL379924 | — | — | 1 | 8.37 |
| CHEMBL210202 | — | — | 1 | 8.23 |
| CHEMBL211010 | — | — | 1 | 8.23 |
| CHEMBL207565 | — | — | 1 | 8.17 |
| CHEMBL377962 | — | — | 1 | 8.16 |
| CHEMBL182739 | — | — | 1 | 8.15 |
| CHEMBL377262 | — | — | 1 | 8.10 |
| CHEMBL379854 | — | — | 1 | 7.92 |
| CHEMBL210473 | — | — | 1 | 7.91 |
| CHEMBL209234 | — | — | 1 | 7.59 |
| CHEMBL377060 | — | — | 1 | 7.45 |
| CHEMBL378138 | — | — | 1 | 7.42 |
| CHEMBL209349 | — | — | 1 | 7.29 |
| CHEMBL321473 | — | — | 1 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL210696 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL210758 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL378694 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL209414 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL379924 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL210202 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL211010 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL207565 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL377962 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL182739 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL377262 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL379854 | — | IC50 | = | 11.9 | nM | 7.92 |
| CHEMBL210473 | — | IC50 | = | 12.3 | nM | 7.91 |
| CHEMBL209234 | — | IC50 | = | 25.7 | nM | 7.59 |
| CHEMBL377060 | — | IC50 | = | 35.3 | nM | 7.45 |
| CHEMBL378138 | — | IC50 | = | 37.6 | nM | 7.42 |
| CHEMBL209349 | — | IC50 | = | 51.2 | nM | 7.29 |
| CHEMBL321473 | — | IC50 | = | 753.0 | nM | 6.12 |