Assay Detail
Functional
CHEMBL868229
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Antiviral potency against HIV1 in CEM/O cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | CEM/O |
| Confidence | 1 — Organism |
| Curated By | Expert |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
cycloSal-PMEA and cycloAmb-PMEA: potentially new phosphonate prodrugs based on the cycloSal-pronucleotide approach.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 5.19 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL922 | ADEFOVIR DIPIVOXIL | 4.0 | 1 | 6.75 |
| CHEMBL197433 | — | — | 1 | 5.52 |
| CHEMBL197483 | — | — | 1 | 5.26 |
| CHEMBL484 | ADEFOVIR | 3.0 | 1 | 5.00 |
| CHEMBL372812 | — | — | 1 | 4.70 |
| CHEMBL197832 | — | — | 1 | 4.55 |
| CHEMBL196867 | — | — | 1 | 4.54 |
| CHEMBL198565 | — | — | 1 | - |
| CHEMBL371100 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL922 | ADEFOVIR DIPIVOXIL | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL197433 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL197483 | — | EC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL484 | ADEFOVIR | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL372812 | — | EC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL197832 | — | EC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL196867 | — | EC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL198565 | — | EC50 | - | — | - | |
| CHEMBL371100 | — | EC50 | - | — | - |